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Wholesale Dealers of Bevacizumab - L-Hydroxyproline Cas: 51-35-4 White powder – XD BIOCHEM

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Wholesale Dealers of Bevacizumab - L-Hydroxyproline Cas: 51-35-4 White powder – XD BIOCHEM Detail:

Catalog Number XD90292
Product Name L-Hydroxyproline

CAS

51-35-4

Molecular Formula

C5H9NO3

Molecular Weight

131.13
Storage Details Ambient

Harmonized Tariff Code

2933998040

 

Product Specification

Assay 99%
Appearance White powder

 

Idiopathic pulmonary fibrosis is thought to involve lung injury caused by reactive oxygen species (ROS), which in turn is followed by abnormal fibrosis. A transforming growth factor (TGF)-β1-induced increase in myofibroblast number plays an important role in this abnormal fibrosis. We recently found that mepenzolate bromide (mepenzolate), which has been used clinically to treat gastrointestinal disorders, has ROS-reducing properties. In the present study, we examined the effect of mepenzolate on bleomycin-induced pulmonary fibrosis and lung dysfunction in mice. The severity of pulmonary fibrosis was assessed by histopathologic evaluation and determination of hydroxyproline levels. Lung mechanics (elastance) and respiratory function [forced vital capacity (FVC)] were assessed using a computer-controlled ventilator. Respiratory function was also evaluated by monitoring percutaneous arterial oxygen saturation (SpO2). Intratracheal administration of mepenzolate prior to bleomycin treatment reduced the extent of pulmonary fibrosis and changes in lung mechanics and led to a significant recovery of both FVC and SpO2 compared with control. Furthermore, mepenzolate produced a therapeutic effect even when it was administered after the development of fibrosis. Administration of mepenzolate also prevented bleomycin-induced pulmonary cell death and inflammatory responses and increased myofibroblast number. Mepenzolate also decreased NADPH oxidase activity and active TGF-β1 level or increased glutathione S-transferase (GST) activity in the presence of bleomycin treatment. These results show that the intratracheal administration of mepenzolate reduced bleomycin-induced pulmonary fibrosis and lung dysfunction in mice. These effects may be due to this drug’s inhibitory effect on NADPH oxidase and TGF-β1 activities and its stimulatory effect on GST.

 


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Our enterprise since its inception, usually regards product top quality as business life, repeatedly enhance manufacturing technology, make improvements to product excellent and continuously strengthen enterprise total high quality administration, in strict accordance with all the national standard ISO 9001:2000 for Wholesale Dealers of Bevacizumab - L-Hydroxyproline Cas: 51-35-4 White powder – XD BIOCHEM , The product will supply to all over the world, such as: Slovak Republic, Jamaica, Tanzania, We welcome you to visit our company & factory and our showroom displays various products that will meet your expectations. Meanwhile, it is convenient to visit our website. Our sales staff will try their best to provide you with the best services. If you need more information, please do not hesitate to contact us via E-mail, fax or telephone.
  • Production management mechanism is completed, quality is guaranteed, high credibility and service let the cooperation is easy, perfect!
    5 Stars By Doris from Italy - 2017.07.28 15:46
    We have been appreciated the Chinese manufacturing, this time also did not let us disappoint,good job!
    5 Stars By Cindy from United States - 2018.09.08 17:09
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    Wholesale Dealers of Bevacizumab - L-Hydroxyproline Cas: 51-35-4 White powder – XD BIOCHEM