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Top Quality Gilead Sciences - Poly-L-lysine solution ( 0.1%) Cas: 25988-63-0 – XD BIOCHEM

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We support our prospective buyers with ideal top quality merchandise and superior level provider. Becoming the specialist manufacturer in this sector, we have now attained abundant practical expertise in producing and managing for 3-Nitrophenyl-Beta-D-Galactopyranoside, 67-42-5, 102783-62-0, We honor our core principal of Honesty in business, priority in company and will do our greatest to provide our customers with high-quality goods and fantastic provider.
Top Quality Gilead Sciences - Poly-L-lysine solution ( 0.1%) Cas: 25988-63-0 – XD BIOCHEM Detail:

Catalog Number XD90306
Product Name Poly-L-lysine solution ( 0.1%)

CAS

25988-63-0

Molecular Formula

C18H38N6O4

Molecular Weight

402.532124042511
Storage Details 2-8°C

 

Product Specification

Assay 0.1%
Appearance Colorless liquid

 

eucine-rich repeat kinase 2 (LRRK2) mutations are the most common known cause of Parkinson’s disease (PD). The clinical features of LRRK2 PD are indistinguishable from idiopathic PD, with accumulation of α-synuclein and/or tau and/or ubiquitin in intraneuronal aggregates. This suggests that LRRK2 is a key to understanding the aetiology of the disorder. Although loss-of-function does not appear to be the mechanism causing PD in LRRK2 patients, it is not clear how this protein mediates toxicity. In this study, we report that LRRK2 overexpression in cells and in vivo impairs the activity of the ubiquitin-proteasome pathway, and that this accounts for the accumulation of diverse substrates with LRRK2 overexpression. We show that this is not mediated by large LRRK2 aggregates or sequestration of ubiquitin to the aggregates. Importantly, such abnormalities are not seen with overexpression of the related protein LRRK1. Our data suggest that LRRK2 inhibits the clearance of proteasome substrate s upstream of proteasome catalytic activity, favouring the accumulation of proteins and aggregate formation. Thus, we provide a molecular link between LRRK2, the most common known cause of PD, and its previously described phenotype of protein accumulation.


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To meet the customers' over-expected pleasure , now we have our potent staff to offer our greatest general service which includes internet marketing, sales, planning, output, quality controlling, packing, warehousing and logistics for Top Quality Gilead Sciences - Poly-L-lysine solution ( 0.1%) Cas: 25988-63-0 – XD BIOCHEM , The product will supply to all over the world, such as: Greenland, Borussia Dortmund, Mombasa, We care about every steps of our services, from factory selection, product development & design, price negotiation, inspection, shipping to aftermarket. Now we have implemented a strict and complete quality control system, which ensures that each product can meet quality requirements of customers. Besides, all of our solutions have been strictly inspected before shipment. Your Success, Our Glory: Our aim is to help customers realize their goals. We're making great efforts to achieve this win-win situation and sincerely welcome you to join us.
  • In general, we are satisfied with all aspects, cheap, high-quality, fast delivery and good procuct style, we will have follow-up cooperation!
    5 Stars By Edwina from Stuttgart - 2018.06.18 17:25
    With a positive attitude of "regard the market, regard the custom, regard the science", the company works actively to do research and development. Hope we have a future business relationships and achieving mutual success.
    5 Stars By Letitia from Yemen - 2018.05.22 12:13
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    Top Quality Gilead Sciences - Poly-L-lysine solution ( 0.1%) Cas: 25988-63-0 – XD BIOCHEM