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Top Quality Gilead Sciences - L-Tryptophan Cas: 73-22-3 99% White powder – XD BIOCHEM

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Top Quality Gilead Sciences - L-Tryptophan Cas: 73-22-3 99% White powder – XD BIOCHEM Detail:

Catalog Number XD90295
Product Name L-Tryptophan

CAS

73-22-3

Molecular Formula

C11H12N2O2

Molecular Weight

204.22518
Storage Details Ambient

Harmonized Tariff Code

29339980

 

Product Specification

Assay 99%min
Appearance White powder
Grade USP32
Specific rotation -29.4 to -32.8
pH 5.5 to 7.0
Fe <0.003%
Pb <0.0015%
Loss on Drying <0.3%
Residue on Ignition 0.1%max
Cl 0.05%max

 

Indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO) are two structurally different enzymes that have a different tissue distribution and physiological roles, but both catalyze the conversion of tryptophan to N-formylkynurenine (NFK). IDO1 has been clinically validated as a small-molecule drug target for cancer, while preclinical studies indicate that TDO may be a target for cancer immunotherapy and neurodegenerative disease. We have developed a high-throughput screening assay for IDO1 and TDO based on a novel chemical probe, NFK Green, that reacts specifically with NFK to form a green fluorescent molecule with an excitation wavelength of 400 nm and an emission wavelength of 510 nm. We provide the first side-by-side comparison of a number of published inhibitors of IDO1 and TDO and reveal that the preclinical IDO1 inhibitor Compound 5l shows significant cross-reactivity with TDO, while the relative selectivity of other published inhibitors was confirmed. The suitabil ity for high-throughput screening of the assays was demonstrated by screening a library of 87,000 chemical substances in 384- or 1536-well format. Finally, we demonstrate that the assay can also be used to measure the capacity of cells to metabolize tryptophan and to measure the cellular potency of IDO1 and TDO inhibitors.


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    Top Quality Gilead Sciences - L-Tryptophan Cas: 73-22-3 99% White powder – XD BIOCHEM