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Top Quality Gilead Sciences - DL-Alanine CAS:302-72-7 99% – XD BIOCHEM

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Top Quality Gilead Sciences - DL-Alanine CAS:302-72-7 99% – XD BIOCHEM Detail:

Catalog Number XD90327
Product Name DL-Alanine
CAS 302-72-7
Molecular Formula C3H7NO2
Molecular Weight 89.09
Storage Details Ambient
Harmonized Tariff Code 29224985

 

Product Specification

Catalog Number XD90327
Product Name DL-Alanine
CAS 302-72-7
Molecular Formula C3H7NO2
Molecular Weight 89.09
Storage Details Ambient
Harmonized Tariff Code 29224985

 

The effectiveness of antibiotic molecules in treating Pseudomonas aeruginosa pneumonia is reduced as a result of the dissemination of bacterial resistance. The existence of bacterial communication systems, such as quorum sensing, has provided new opportunities of treatment. Lactonases efficiently quench acyl-homoserine lactone-based bacterial quorum sensing, implicating these enzymes as potential new anti-Pseudomonas drugs that might be evaluated in pneumonia.The aim of the present study was to evaluate the ability of a lactonase called SsoPox-I to reduce the mortality of a rat P. aeruginosa pneumonia.To assess SsoPox-I-mediated quorum quenching, we first measured the activity of the virulence gene lasB, the synthesis of pyocianin, the proteolytic activity of a bacterial suspension and the formation of biofilm of a PAO1 strain grown in the presence of lactonase. In an acute lethal model of P. aeruginosa pneumonia in rats, we evaluated the effects of an early or deferred intra-tracheal treatment with SsoPox-I on the mortality, lung bacterial count and lung damage.SsoPox-I decreased PAO1 lasB virulence gene activity, pyocianin synthesis, proteolytic activity and biofilm formation. The early use of SsoPox-I reduced the mortality of rats with acute pneumonia from 75% to 20%. Histological lung damage was significantly reduced but the lung bacterial count was not modified by the treatment. A delayed treatment was associated with a non-significant reduction of mortality.These results demonstrate the protective effects of lactonase SsoPox-I in P. aeruginosa pneumonia and open the way for a future therapeutic use.


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Our growth depends around the superior machines, exceptional talents and consistently strengthened technology forces for Top Quality Gilead Sciences - DL-Alanine CAS:302-72-7 99% – XD BIOCHEM , The product will supply to all over the world, such as: Germany, Spain, Netherlands, Our products are mainly exported to Europe, Africa, America, the Middle East and Southeast Asia and other countries and regions. We have enjoyed a great reputation among our customers for quality products and good services.We would make friends with businessmen from at home and abroad, following the purpose of "Quality First, Reputation First, the Best Services."
  • This supplier's raw material quality is stable and reliable, has always been in accordance with the requirements of our company to provide the goods that quality meet our requirements.
    5 Stars By Faithe from Roman - 2017.09.30 16:36
    This manufacturer can keep improving and perfecting products and service, it is in line with the rules of market competition, a competitive company.
    5 Stars By Edith from Denver - 2018.06.12 16:22
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    Top Quality Gilead Sciences - DL-Alanine CAS:302-72-7 99% – XD BIOCHEM