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Tazobactam Cas: 89786-04-9

Short Description:

Catalog Number: XD92373
Cas: 89786-04-9
Molecular Formula: C10H12N4O5S
Molecular Weight: 300.29
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Product Detail

Product Tags

Catalog Number XD92373
Product Name Tazobactam
CAS 89786-04-9
Molecular Formula C10H12N4O5S
Molecular Weight 300.29
Storage Details -15 to -20 °C
Harmonized Tariff Code 29419000

Product Specification

Appearance White to off-white powder
Assay 99% min
Water <0.5%
Specific rotation +127 to +139
Heavy metals <20ppm
Residue on Ignition <0.1%
Total Impurities <1.0%

 

Tazobactam is a penicillanic acid sulfone that is similar instructure to sulbactam. It is a more potent β-lactamaseinhibitor than sulbactam and has a slightly broader spectrumof activity than clavulanic acid. It has very weak antibacterialactivity. Tazobactam is available in fixed-dose, injectablecombinations with piperacillin, a broad-spectrum penicillinconsisting of an 8:1 ratio of piperacillin sodium to tazobactamsodium by weight and marketed under the trade name Zosyn.The pharmacokinetics of the two drugs are very similar. Bothhave short half-lives (t1/2 ~1 hour), are minimally proteinbound, experience very little metabolism, and are excreted inactive forms in the urine in high concentrations.

Approved indications for the piperacillin–tazobactamcombination include the treatment of appendicitis, postpartumendometritis, and pelvic inflammatory disease caused byβ-lactamase–producing E. coli and Bacteroides spp., skin andskin structure infections caused by β-lactamase–producingS. aureus, and pneumonia caused by β-lactamase–producingstrains of H. influenzae.


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    Tazobactam Cas: 89786-04-9