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Spectinomycin dihydrochloride pentahydrate CAS:22189-32-8 White crystaline powder

Short Description:

Catalog Number: XD90369
CAS: 22189-32-8
Molecular Formula: C14H24N2O7·2HCl·5H2O
Molecular Weight: 495.30
Availability: In Stock
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Prepack: 25g USD20
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Product Detail

Product Tags

Catalog Number XD90369
Product Name Spectinomycin dihydrochloride pentahydrate
CAS 22189-32-8
Molecular Formula C14H24N2O7·2HCl·5H2O
Molecular Weight 495.30
Storage Details 2 to 8 °C
Harmonized Tariff Code 29419090

 

Product Specification

Assay 99%
Appearance White crystaline powder

 

To investigate the molecular epidemiology of isolates of Neisseria gonorrhoeae from Saskatchewan, Canada, using Neisseria gonorrhoeae multi antigen sequence typing (NG-MAST), and to assess associations between antimicrobial susceptibility (AMS) and specific strain types (STs).320 consecutive gonococcal isolates, collected between 2003 and 2008, were typed by NG-MAST. STs were grouped if one of their alleles was common and the other differed by ≤1% in DNA sequence. AMS was determined by agar dilution (CLSI) to seven antibiotics.N gonorrhoeae isolates were resolved into 82 individual NG-MAST STs and 18 NG-MAST ST groups with groups 25, 3655, 921, 3654, 3657 and 3656 comprising 53.4% (171/320) of the isolates. N gonorrhoeae isolates susceptible to all the tested antimicrobials were significantly (p<0.05) associated with ST 25 (87%). Other significant associations between ST and AMS included: ST 3654 and isolates with minimum inhibitory concentrations of ≥0.03 mg/L to third generation ceph alosporins; ST 3711 (100%) and TRNG; and ST/group 3654 (43%) and chromosomal resistance to penicillin and tetracycline. Several NG-MAST STs/groups were significantly associated with isolates with chromosomal resistance to tetracycline. Isolates resistant to ciprofloxacin (n=5) and azithromycin (n=2) appeared as individual STs. Significant associations were observed among individual STs, sex and age of the patient, and regional and temporal distributions.Associations between N gonorrhoeae AMS and NG-MAST STs were identified and may be useful in predicting AMS regionally. Because STs in different countries vary considerably, the use of NG-MAST for the prediction of AMS globally requires further study.


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    Spectinomycin dihydrochloride pentahydrate CAS:22189-32-8 White crystaline powder