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Special Design for Egtazic Acid - 5-Sulfosalicylic acid dihydrate Cas: 5965-83-3 White to off-white crystal – XD BIOCHEM

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Special Design for Egtazic Acid - 5-Sulfosalicylic acid dihydrate Cas: 5965-83-3 White to off-white crystal – XD BIOCHEM Detail:

Catalog Number XD90230
Product Name 5-Sulfosalicylic acid dihydrate

CAS

5965-83-3

Molecular Formula

C7H10O8S

Molecular Weight

254.215
Storage Details Ambient

Harmonized Tariff Code

29182900

 

Product Specification

Sulfate 5.5% max
Moisture 22% max
Appearance White to off-white crystal
Total acid 99 – 104%
Assay 99%

 

Polycations are explored as carriers to deliver therapeutic nucleic acids. Polycations are conventionally pharmacological inert with the sole function of delivering therapeutic cargo. This study reports synthesis of a self-immolative polycation (DSS-BEN) based on a polyamine analogue drug N(1),N(11)-bisethylnorspermine (BENSpm). The polycation was designed to function dually as a gene delivery carrier and a prodrug targeting dysregulated polyamine metabolism in cancer. Using a combination of NMR and HPLC, we confirm that the self-immolative polycation undergoes intracellular degradation into the parent drug BENSpm. The released BENSpm depletes cellular levels of spermidine and spermine and upregulates polyamine catabolic enzymes spermine/spermidine N(1)-acetyltransferase (SSAT) and spermine oxidase (SMO). The synthesized polycations form polyplexes with DNA and facilitate efficient transfection. Taking advantage of the ability of BENSpm to sensitize cancer cells to TNFα-induced apoptos is, we show that DSS-BEN enhances the cell killing activity of TNFα gene therapy. The reported findings validate DSS-BEN as a dual-function delivery system that can deliver a therapeutic gene and improve the outcome of gene therapy as a result of the intracellular degradation of DSS-BEN to BENSpm and the subsequent beneficial effect of BENSpm on dysregulated polyamine metabolism in cancer.

 


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Special Design for Egtazic Acid - 5-Sulfosalicylic acid dihydrate  Cas: 5965-83-3  White to off-white crystal – XD BIOCHEM detail pictures


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    Special Design for Egtazic Acid - 5-Sulfosalicylic acid dihydrate Cas: 5965-83-3 White to off-white crystal – XD BIOCHEM