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Renewable Design for Dipso Sodium - N-(2-Acetamide)iminodiacetic acid Cas: 26239-55-4 99% White powder – XD BIOCHEM

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Renewable Design for Dipso Sodium - N-(2-Acetamide)iminodiacetic acid Cas: 26239-55-4 99% White powder – XD BIOCHEM Detail:

Catalog Number XD90194
Product Name ADA (N-(-2-Acetamido)iminodiacetic acid) 

CAS

26239-55-4

Molecular Formula

C6H10N2O5

Molecular Weight

190.15
Storage Details Ambient
Harmonized Tariff Code 29241900

 

Product Specification

Fe <5ppm
Pb <5ppm
Loss on Drying <0.5%
Sulfated ash <0.1%
Appearance White powder
Other Solvents None
Dissolution Time (9g in 91ml 1M NaOH, Magnetic Stirring)

<1min

A300 ( 9% in 1 M NaOH)

<0.08%

Number of endpoints Observed in the titration curve

Two only

pH Range that Defines the Titration Second Endpoint

9.1 – 10.1

Solubility (9% in 1M NaOH) Clear and Colourless
Manufacture date  
Water KF <1%
Assay (Titration) on dried basis

>99.0%

Infrared Complies

 

The nucleoside adenosine acts on the nervous and cardiovascular systems via the A2A receptor (A2AR). In response to oxygen level in tissues, adenosine plasma concentration is regulated in particular via its synthesis by CD73 and via its degradation by adenosine deaminase (ADA). The cell-surface endopeptidase CD26 controls the concentration of vasoactive and antioxidant peptides and hence regulates the oxygen supply to tissues and oxidative stress response. Although overexpression of adenosine, CD73, ADA, A2AR, and CD26 in response to hypoxia is well documented, the effects of hyperoxic and hyperbaric conditions on these elements deserve further consideration. Rats and a murine Chem-3 cell line that expresses A2AR were exposed to 0.21 bar O2, 0.79 bar N2 (terrestrial conditions; normoxia); 1 bar O2 (hyperoxia); 2 bar O2 (hyperbaric hyperoxia); 0.21 bar O2, 1.79 bar N2 (hyperbaria). Adenosine plasma concentration, CD73, ADA, A2AR expression, and CD26 activity were addressed in vivo, and cAMP production was addressed in cellulo. For in vivo conditions, 1) hyperoxia decreased adenosine plasma level and T cell surface CD26 activity, whereas it increased CD73 expression and ADA level; 2) hyperbaric hyperoxia tended to amplify the trend; and 3) hyperbaria alone lacked significant influence on these parameters. In the brain and in cellulo, 1) hyperoxia decreased A2AR expression; 2) hyperbaric hyperoxia amplified the trend; and 3) hyperbaria alone exhibited the strongest effect. We found a similar pattern regarding both A2AR mRNA synthesis in the brain and cAMP production in Chem-3 cells. Thus a high oxygen level tended to downregulate the adenosinergic pathway and CD26 activity. Hyperbaria alone affected only A2AR expression and cAMP production. We discuss how such mechanisms triggered by hyperoxygenation can limit, through vasoconstriction, the oxygen supply to tissues and the production of reactive oxygen species.


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Renewable Design for Dipso Sodium - N-(2-Acetamide)iminodiacetic acid  Cas: 26239-55-4 99%  White powder – XD BIOCHEM detail pictures


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We support our purchasers with ideal premium quality products and substantial level company. Becoming the specialist manufacturer in this sector, we've acquired rich practical working experience in producing and managing for Renewable Design for Dipso Sodium - N-(2-Acetamide)iminodiacetic acid Cas: 26239-55-4 99% White powder – XD BIOCHEM , The product will supply to all over the world, such as: Thailand, Houston, Chile, If any item be of interest to you, you should let us know. We will try our best to satisfy your requirements with high quality goods, the best prices and prompt delivery. You should feel free to contact us at any time. We will reply you when we receive your inquiries. Make sure you note that samples are available before we start our business.
  • We are a small company that has just started, but we get the company leader's attention and gave us a lot of help. Hope we can make progress together!
    5 Stars By olivier musset from Tunisia - 2017.06.19 13:51
    We are a small company that has just started, but we get the company leader's attention and gave us a lot of help. Hope we can make progress together!
    5 Stars By Lena from Romania - 2017.05.31 13:26
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    Renewable Design for Dipso Sodium - N-(2-Acetamide)iminodiacetic acid Cas: 26239-55-4 99% White powder – XD BIOCHEM