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Renewable Design for Bristol-Myers Squibb - L-Cysteine hydrochloride anhydrous CAS:52-89-1 99% White crystalline powder – XD BIOCHEM

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Renewable Design for Bristol-Myers Squibb - L-Cysteine hydrochloride anhydrous CAS:52-89-1 99% White crystalline powder – XD BIOCHEM Detail:

Catalog Number XD90319
Product Name L-Cysteine hydrochloride anhydrous
CAS 52-89-1
Molecular Formula C3H7NO2S·HCl
Molecular Weight 157.62
Storage Details 2 to 8 °C
Harmonized Tariff Code 29309016

 

Product Specification

Appearance White crystalline powder
Assay 99%
Specific rotation +5.6 – +8.9
Conclusion AJI92 Grade
Heavy metals <10ppm
Identification Infrared absorption spectrum
pH 1.5 – 2
Loss on Drying <2.0%
Residue on Ignition <0.1%
Other amino acids Chromatographically not detectable
Arsenic (as As2O3) <1ppm

 

he major risk factor for Clostridium difficile infection (CDI) is the use of antibiotics owing to the disruption of the equilibrium of the host gut microbiota. To preserve the beneficial resident probiotic bacteria during infection treatment, the use of molecules with selective antibacterial activity enhances the efficacy by selectively removing C. difficile. One of them is the plant alkaloid 8-hydroxyquinoline (8HQ), which has been shown to selectively inhibit clostridia without repressing bifidobacteria. Selective antimicrobial activity is generally tested by culture techniques of individual bacterial strains. However, the main limitation of these techniques is the inability to describe differential growth dynamics of more bacterial strains in co-culture within the same experiment. In the present study, we combined fluorescent in situ hybridization and flow cytometry to describe the changes in active and non-active cells of a mixed culture formed by the opportunistic pathogen C. diff icile CECT 531 and the beneficial Bifidobacterium longum subsp. longum CCMDMND BL1 after exposure to 8HQ. It was observed that without 8HQ, the proportion of both strains was almost equal, oscillating between 22.7 and 77.9 % during a time lapse of 12 h, whereas with 8HQ the proportion of active C. difficile decreased after 4 h, and persisted only between 8.8 and 17.5 %. In contrast, bifidobacterial growth was not disturbed by 8HQ. The results of this study showed the selective inhibitory effect of 8HQ on clostridial and bifidobacterial growth dynamics, and the potential of this compound for the development of selective agents to control CDIs.


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    Renewable Design for Bristol-Myers Squibb - L-Cysteine hydrochloride anhydrous CAS:52-89-1 99% White crystalline powder – XD BIOCHEM