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PVP-K30 Cas: 9003-39-8 White to yellowish white powder

Short Description:

Catalog Number: XD90232
Cas: 9003-39-8
Molecular Formula: C8H15NO
Molecular Weight: 141.2108
Availability: In Stock
Price:  
Prepack: 100g USD10
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Product Detail

Product Tags

Catalog Number XD90232
Product Name PVP-K30

CAS

9003-39-8

Molecular Formula

C8H15NO

Molecular Weight

141.2108
Storage Details Ambient

Harmonized Tariff Code

39059990

 

Product Specification

Water <5%
Heavy metals <10ppm
pH 3 - 7
Residue on Ignition <0.1%
Aldehydes 0.05% max
Nitrogen 11.5 - 12.8%
Appearance White to yellowish white powder
K Value 27 - 32.4
Hydrazine 1.0% max
Assay 99%

 

We have investigated the physical stability of amorphous curcumin dispersions and the role of curcumin-polymer intermolecular interactions in delaying crystallization. Curcumin is an interesting model compound as it forms both intra and intermolecular hydrogen bonds in the crystal. A structurally diverse set of amorphous dispersion polymers was investigated; poly(vinylpyrrolidone), Eudragit E100, carboxymethyl cellulose acetate butyrate, hydroxypropyl methyl cellulose (HPMC) and HPMC-acetate succinate. Mid-infrared spectroscopy was used to determine and quantify the extent of curcumin-polymer interactions. Physical stability under different environmental conditions was monitored by powder X-ray diffraction. Curcumin chemical stability was monitored by UV-Vis spectroscopy. Isolation of stable amorphous curcumin was difficult in the absence of polymers. Polymers proved to be effective curcumin crystallization inhibitors enabling the production of amorphous solid dispersions; however, the polymers showed very different abilities to inhibit crystallization during long-term storage. Curcumin intramolecular hydrogen bonding reduced the extent of its hydrogen bonding with polymers; hence most polymers were not highly effective crystallization inhibitors. Overall, polymers proved to be crystallization inhibitors, but inhibition was limited due to the intramolecular hydrogen bonding in curcumin, which leads to a decrease in the ability of the polymers to interact at a molecular level.


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    PVP-K30 Cas: 9003-39-8 White to yellowish white powder