PHENYL-1-THIO-β-D-GALACTOPYRANOSIDE Cas:16758-34-2 95% White powder
Catalog Number | XD90049 |
Product Name | PHENYL-1-THIO-β-D-GALACTOPYRANOSIDE |
CAS | 16758-34-2 |
Molecular Formula | C12H16O5S |
Molecular Weight | 272.32 |
Storage Details | Ambient |
Product Specification
Appearance | White powder |
Assay | 95% min |
storage Temp. | 2-8°C |
optical Activity | [α]22/D -48.0°,c = 0.5% |
Mp | 93-98 °C |
Binding of substituted phenyl 1-thio-β-D-galactopyranosides to β-D-galactosidase from e.
The binding of a series of substituted phenyl 1-thio-β-D-galactopyranosides to the active site ofβ-D-galactosidase from E. coli has been investigated. The inhibition constants and the standard free energy of transfer ΔG°(K1) were compared with the partition coeficients and ΔG° (1-octanol) values of these inhibitor molecules in a model 1-octanol-water system. All of the evidence available suggests that the aglycon group of the inhibitor is bound to the active site unspecific, hydrophobic forces. Correlations between ΔG° (K1) and ΔG° (1-octanol) could not be found for the whole series, but only for simpler sub-series. Probably, the octanol system is too incomplete a model for the hydrophobic region in the active site ofβ-D-galactosidase.