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Pemetrexed disodium, also known by its international nonproprietary name (INN) as Pemetrexed INT-3, is a chemotherapy medication used in the treatment of various types of cancer. It belongs to a class of drugs known as antifolate antineoplastic agents and works by inhibiting the action of certain enzymes involved in the replication and repair of DNA, ultimately slowing down or stopping the growth of cancer cells.Pemetrexed disodium is primarily indicated for the treatment of advanced non-small cell lung cancer (NSCLC), which is the most common type of lung cancer. It is often administered in combination with other chemotherapy drugs, such as cisplatin, to enhance its efficacy. Pemetrexed disodium has also demonstrated effectiveness in the treatment of malignant pleural mesothelioma, a rare form of cancer that affects the lining of the lungs and other organs.The administration of Pemetrexed disodium is typically done intravenously, which allows for direct delivery into the bloodstream. The dosage and treatment schedule may vary depending on the specific cancer being treated, the patient's overall health condition, and other factors determined by the healthcare provider. Regular monitoring of blood cell counts, liver function, and kidney function is usually required during treatment to assess the drug's tolerability and efficacy.Pemetrexed disodium can be associated with side effects, although their severity and occurrence may vary from person to person. Common side effects include fatigue, nausea, vomiting, decreased appetite, diarrhea, and skin rash. These side effects are usually manageable and temporary, but it is important for patients to communicate any discomfort or concerns to their healthcare team for appropriate support and management.As with any medication, there are some precautions and contraindications associated with Pemetrexed disodium. It is typically not recommended for use in patients with severe kidney or liver disease, those who are pregnant or breastfeeding, or individuals with known hypersensitivity to the drug. It is crucial for healthcare professionals to assess a patient's medical history and overall condition before initiating treatment with Pemetrexed disodium.In conclusion, Pemetrexed disodium INT-3 is a chemotherapy medication used in the treatment of advanced non-small cell lung cancer and malignant pleural mesothelioma. It works by inhibiting DNA replication and repair, thereby slowing down or stopping the growth of cancer cells. While it has shown efficacy in certain cancers, it is important to consider individual patient factors and closely monitor for potential side effects during treatment.