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Online Exporter Pharmaceutical Intermediates - L-Glutamic acid CAS:56-86-0 99% White Powder – XD BIOCHEM

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Online Exporter Pharmaceutical Intermediates - L-Glutamic acid CAS:56-86-0 99% White Powder – XD BIOCHEM Detail:

Catalog Number XD90312
Product Name D-Glutamic acid
CAS 56-86-0
Molecular Formula C5H9NO4
Molecular Weight 147.13
Storage Details Ambient
Harmonized Tariff Code 29224200

 

Product Specification

Appearance White Crystal or Crystalline Powder
Assay 99%
Specific rotation +31.5 to +32.5°
pH 3.0 to 3.5
Loss on Drying 0.2% max
Iron 10 ppm max
AS2O3 1 ppm max
Heavy metal(Pb) 10 ppm max
Ammonium 0.02% max
Other amino acids <0.4%
Chloride 0.02% max.
Residue on Ignition (Sulfated) 0.1% max
Sulfate (as SO4) 0.02% max

 

he EAAT2 glutamate transporter, accounts for >90% of hippocampal glutamate uptake. Although EAAT2 is predominantly expressed in astrocytes, ∼10% of EAAT2 molecules are found in axon terminals. Despite the lower level of EAAT2 expression in glutamatergic terminals, when hippocampal slices are incubated with low concentration of d-aspartate (an EAAT2 substrate), axon terminals accumulate d-aspartate as quickly as astroglia. This implies an unexplained mismatch between the distribution of EAAT2 protein and of EAAT2-mediated transport activity. One hypothesis is that (1) heteroexchange of internal substrate with external substrate is considerably faster than net uptake and (2) terminals favor heteroexchange because of high levels of internal glutamate. However, it is currently unknown whether heteroexchange and uptake have similar or different rates. To address this issue, we used a reconstituted system to compare the relative rates of the two processes in rat and mice. Net uptake was sens itive to changes in the membrane potential and was stimulated by external permeable anions in agreement with the existence of an uncoupled anion conductance. By using the latter, we also demonstrate that the rate of heteroexchange also depends on the membrane potential. Additionally, our data further suggest the presence of a sodium leak in EAAT2. By incorporating the new findings in our previous model of glutamate uptake by EAAT2, we predict that the voltage sensitivity of exchange is caused by the voltage-dependent third Na(+) binding. Further, both our experiments and simulations suggest that the relative rates of net uptake and heteroexchange are comparable in EAAT2.


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    5 Stars By Renee from Uruguay - 2017.08.16 13:39
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    5 Stars By Faithe from Cologne - 2018.06.18 19:26
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    Online Exporter Pharmaceutical Intermediates - L-Glutamic acid CAS:56-86-0 99% White Powder – XD BIOCHEM