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Online Exporter Ados - 4-Fluoro-7-nitrobenzofurazan Cas: 29270-56-2 99% Solid – XD BIOCHEM

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We offer wonderful energy in high-quality and improvement,merchandising,product sales and marketing and advertising and procedure for Amino Acid Derivative, Mes Hemisodium Salt, 14218-11-2, We have been in operation for more than 10 years. We are dedicated to quality products and consumer support. We invite you to visit our company for a personalized tour and advanced business guidance.
Online Exporter Ados - 4-Fluoro-7-nitrobenzofurazan Cas: 29270-56-2 99% Solid – XD BIOCHEM Detail:

Catalog Number XD90223
Product Name 4-Fluoro-7-nitrobenzofurazan

CAS

29270-56-2

Molecular Formula

C6H2FN3O3

Molecular Weight

183.0968
Storage Details Under -20°C
Harmonized Tariff Code 2934999090

 

Product Specification

Appearance Solid
Assay 99%

 

Submillimolar concentrations of cytotoxic bile acids (BAs) induce cell death via apoptosis. On the other hand, several cytoprotective BAs were shown to prevent apoptosis in the same concentration range. Still, the mechanisms by which BAs trigger these opposite signaling effects remain unclear. This study was aimed to determine if cytotoxic and cytoprotective BAs, at physiologically active concentrations, are able to modulate the biophysical properties of lipid membranes, potentially translating into changes in the apoptotic threshold of cells. Binding of BAs to membranes was assessed through the variation of fluorescence parameters of suitable derivatized BAs. These derivatives partitioned with higher affinity to liquid disordered than to the cholesterol-enriched liquid ordered domains. Unlabeled BAs were also shown to have a superficial location upon interaction with the lipid membrane. Additionally, the interaction of cytotoxic BAs with membranes resulted in membrane expansion, as co ncluded from FRET data. Moreover, it was shown that cytotoxic BAs were able to significantly disrupt the ordering of the membrane by cholesterol at physiologically active concentrations of the BA, an effect not associated with cholesterol removal. On the other hand, cytoprotective bile acids had no effect on membrane properties. It was concluded that, given the observed effects on membrane rigidity, the apoptotic activity of cytotoxic BAs could be potentially associated with changes in plasma membrane organization (e.g. modulation of lipid domains) or with an increase in mitochondrial membrane affinity for apoptotic proteins.


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Our target is to consolidate and improve the quality and service of existing products, meanwhile constantly develop new products to meet different customers' demands for Online Exporter Ados - 4-Fluoro-7-nitrobenzofurazan Cas: 29270-56-2 99% Solid – XD BIOCHEM , The product will supply to all over the world, such as: Islamabad, Kyrgyzstan, Los Angeles, Our well-equipped facilities and excellent quality control throughout all stages of production enable us to guarantee total customer satisfaction. If you are interested in any of our products or would like to discuss a custom order, please feel free to contact me. We are looking forward to forming successful business relationship with new clients around the world.
  • The factory can meet continuously developing economic and market needs, so that their products are widely recognized and trusted, and that's why we chose this company.
    5 Stars By Jodie from UK - 2018.06.28 19:27
    It is really lucky to meet such a good supplier, this is our most satisfied cooperation, I think we will work again!
    5 Stars By Jill from Danish - 2018.09.19 18:37
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    Online Exporter Ados - 4-Fluoro-7-nitrobenzofurazan Cas: 29270-56-2 99% Solid – XD BIOCHEM