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One of Hottest for Pfizer - D-Valine Cas: 640-68-6 C5H11NO2 – XD BIOCHEM

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Gaining purchaser gratification is our company's aim eternally. We're going to make great initiatives to create new and top-quality products, satisfy your exclusive prerequisites and supply you with pre-sale, on-sale and after-sale solutions for Beta-D-Glucose Pentaacetate, Organic Intermediate, Difficult-To-Make Chiral Building Blocks, The team of our company with the use of cutting-edge technologies delivers impeccable quality products supremely adored and appreciated by our customers worldwide.
One of Hottest for Pfizer - D-Valine Cas: 640-68-6 C5H11NO2 – XD BIOCHEM Detail:

Catalog Number XD90291
Product Name D-Valine

CAS

640-68-6

Molecular Formula

C5H11NO2

Molecular Weight

117.14634
Storage Details Room Temp

Harmonized Tariff Code

29224995

 

Product Specification

Assay 99%
Appearance White powder
Density 1.2000 (estimate)
Melting point >295 °C (subl.) (lit.)
Boiling point 213.6 °C at 760 mmHg
Flash point 83℃
Refractive index -27 ° (C=8, 6mol/L HCl)
Solubility 56 g/L (20°C)
Water solubility 56 g/L (20 ºC)
PSA 63.32000
LogP 0.75460
Specific rotation -27.5 º (c=5, 5N HCl)
Optical activity [α]23/D −32.0 to −24.0°, c = 8 in 6 M HCl

 

Women with antiphospholipid syndrome (APS) are at increased risk of recurrent pregnancy loss (RPL) and preeclampsia. Antiphospholipid antibodies (aPL) directly alter trophoblast function. Treatment with low molecular weight heparin (LMWH) reduces the risk of RPL but not preeclampsia. Moreover, LMWH stimulates trophoblast sFlt-1 release, an anti-angiogenic factor associated with preeclampsia. Since vitamin D deficiency is associated with APS and preeclampsia, this study sought to determine the effect of vitamin D on trophoblast function in the setting of aPL and LMWH.A human first trimester trophoblast cell line (HTR8) and primary trophoblast cultures were treated with or without aPL in the presence and absence of vitamin D, LMWH or both. Trophoblast secretion of inflammatory cytokines and angiogenic factors were measured by ELISA.Vitamin D alone or in combination with LMWH attenuated the aPL-induced trophoblast inflammatory response in the HTR8 cells and primary cultures. While vitamin D did not have any impact on aPL-mediated modulation of angiogenic factors in the primary trophoblast, it significantly inhibited LMWH-induced sFlt-1 release.LMWH in combination with vitamin D may be more beneficial than single-agent therapy by preventing aPL-induced trophoblast inflammation and reversing LMWH-induced sFlt-1 secretion.


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Our enterprise insists all along the standard policy of "product high-quality is base of business survival; client satisfaction could be the staring point and ending of an business; persistent improvement is eternal pursuit of staff" as well as consistent purpose of "reputation first, client first" for One of Hottest for Pfizer - D-Valine Cas: 640-68-6 C5H11NO2 – XD BIOCHEM , The product will supply to all over the world, such as: Singapore, Bogota, Russia, Our company always concentrate on the development of the international market. We have a lot of customers in Russia , European countries, the USA, the Middle East countries and Africa countries. We always follow that quality is foundation while service is guarantee to meet all customers.
  • Although we are a small company, we are also respected. Reliable quality, sincere service and good credit, we are honored to be able to work with you!
    5 Stars By Fernando from Romania - 2018.10.09 19:07
    Good quality, reasonable prices, rich variety and perfect after-sales service, it's nice!
    5 Stars By Moira from Denmark - 2018.02.21 12:14
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    One of Hottest for Pfizer - D-Valine Cas: 640-68-6 C5H11NO2 – XD BIOCHEM