One of Hottest for Pfizer - D-Valine Cas: 640-68-6 C5H11NO2 – XD BIOCHEM
One of Hottest for Pfizer - D-Valine Cas: 640-68-6 C5H11NO2 – XD BIOCHEM Detail:
Catalog Number | XD90291 |
Product Name | D-Valine |
CAS |
640-68-6 |
Molecular Formula |
C5H11NO2 |
Molecular Weight |
117.14634 |
Storage Details | Room Temp |
Harmonized Tariff Code |
29224995 |
Product Specification
Assay | 99% |
Appearance | White powder |
Density | 1.2000 (estimate) |
Melting point | >295 °C (subl.) (lit.) |
Boiling point | 213.6 °C at 760 mmHg |
Flash point | 83℃ |
Refractive index | -27 ° (C=8, 6mol/L HCl) |
Solubility | 56 g/L (20°C) |
Water solubility | 56 g/L (20 ºC) |
PSA | 63.32000 |
LogP | 0.75460 |
Specific rotation | -27.5 º (c=5, 5N HCl) |
Optical activity | [α]23/D −32.0 to −24.0°, c = 8 in 6 M HCl |
Women with antiphospholipid syndrome (APS) are at increased risk of recurrent pregnancy loss (RPL) and preeclampsia. Antiphospholipid antibodies (aPL) directly alter trophoblast function. Treatment with low molecular weight heparin (LMWH) reduces the risk of RPL but not preeclampsia. Moreover, LMWH stimulates trophoblast sFlt-1 release, an anti-angiogenic factor associated with preeclampsia. Since vitamin D deficiency is associated with APS and preeclampsia, this study sought to determine the effect of vitamin D on trophoblast function in the setting of aPL and LMWH.A human first trimester trophoblast cell line (HTR8) and primary trophoblast cultures were treated with or without aPL in the presence and absence of vitamin D, LMWH or both. Trophoblast secretion of inflammatory cytokines and angiogenic factors were measured by ELISA.Vitamin D alone or in combination with LMWH attenuated the aPL-induced trophoblast inflammatory response in the HTR8 cells and primary cultures. While vitamin D did not have any impact on aPL-mediated modulation of angiogenic factors in the primary trophoblast, it significantly inhibited LMWH-induced sFlt-1 release.LMWH in combination with vitamin D may be more beneficial than single-agent therapy by preventing aPL-induced trophoblast inflammation and reversing LMWH-induced sFlt-1 secretion.
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Our enterprise insists all along the standard policy of "product high-quality is base of business survival; client satisfaction could be the staring point and ending of an business; persistent improvement is eternal pursuit of staff" as well as consistent purpose of "reputation first, client first" for One of Hottest for Pfizer - D-Valine Cas: 640-68-6 C5H11NO2 – XD BIOCHEM , The product will supply to all over the world, such as: Singapore, Bogota, Russia, Our company always concentrate on the development of the international market. We have a lot of customers in Russia , European countries, the USA, the Middle East countries and Africa countries. We always follow that quality is foundation while service is guarantee to meet all customers.
By Fernando from Romania - 2018.10.09 19:07
Good quality, reasonable prices, rich variety and perfect after-sales service, it's nice!
By Moira from Denmark - 2018.02.21 12:14