OEM Manufacturer Tt - DL-Alanine CAS:302-72-7 99% – XD BIOCHEM
OEM Manufacturer Tt - DL-Alanine CAS:302-72-7 99% – XD BIOCHEM Detail:
Catalog Number | XD90327 |
Product Name | DL-Alanine |
CAS | 302-72-7 |
Molecular Formula | C3H7NO2 |
Molecular Weight | 89.09 |
Storage Details | Ambient |
Harmonized Tariff Code | 29224985 |
Product Specification
Catalog Number | XD90327 |
Product Name | DL-Alanine |
CAS | 302-72-7 |
Molecular Formula | C3H7NO2 |
Molecular Weight | 89.09 |
Storage Details | Ambient |
Harmonized Tariff Code | 29224985 |
The effectiveness of antibiotic molecules in treating Pseudomonas aeruginosa pneumonia is reduced as a result of the dissemination of bacterial resistance. The existence of bacterial communication systems, such as quorum sensing, has provided new opportunities of treatment. Lactonases efficiently quench acyl-homoserine lactone-based bacterial quorum sensing, implicating these enzymes as potential new anti-Pseudomonas drugs that might be evaluated in pneumonia.The aim of the present study was to evaluate the ability of a lactonase called SsoPox-I to reduce the mortality of a rat P. aeruginosa pneumonia.To assess SsoPox-I-mediated quorum quenching, we first measured the activity of the virulence gene lasB, the synthesis of pyocianin, the proteolytic activity of a bacterial suspension and the formation of biofilm of a PAO1 strain grown in the presence of lactonase. In an acute lethal model of P. aeruginosa pneumonia in rats, we evaluated the effects of an early or deferred intra-tracheal treatment with SsoPox-I on the mortality, lung bacterial count and lung damage.SsoPox-I decreased PAO1 lasB virulence gene activity, pyocianin synthesis, proteolytic activity and biofilm formation. The early use of SsoPox-I reduced the mortality of rats with acute pneumonia from 75% to 20%. Histological lung damage was significantly reduced but the lung bacterial count was not modified by the treatment. A delayed treatment was associated with a non-significant reduction of mortality.These results demonstrate the protective effects of lactonase SsoPox-I in P. aeruginosa pneumonia and open the way for a future therapeutic use.
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It adheres to the tenet "Honest, industrious, enterprising, innovative" to develop new products constantly. It regards customers, success as its own success. Let us develop prosperous future hand in hand for OEM Manufacturer Tt - DL-Alanine CAS:302-72-7 99% – XD BIOCHEM , The product will supply to all over the world, such as: Egypt, Madrid, Barcelona, We have top engineers in these industries and an efficient team in the research. What is more, we have our own archives mouths and markets in China at low cost. Therefore, we can meet different inquiries from different clients. Please find our website to check more information from our products.
By Sandy from Costa rica - 2017.03.08 14:45
Customer service staff and sales man are very patience and they all good at English, product's arrival is also very timely, a good supplier.
By Joanna from Kenya - 2017.07.07 13:00