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OEM China Da - Glutathione reduced Cas: 70-18-8 98-101% Clear and colourless – XD BIOCHEM

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OEM China Da - Glutathione reduced Cas: 70-18-8 98-101% Clear and colourless – XD BIOCHEM Detail:

Catalog Number XD90284
Product Name Glutathione reduced

CAS

70-18-8

Molecular Formula

C10H17N3O6S

Molecular Weight

307.32
Storage Details 2 to 8 °C

Harmonized Tariff Code

29309098

 

Product Specification

Assay 98% – 101%
Appearance White crystalline powder
Grade EP 7.0
Impurity A <0.5%
Impurity B <0.5%
Heavy metals <10ppm
Bacterial endotoxin <0.10EU/mg
Impurity C <1.5%
Impurity D <1.0%
Loss on Drying <0.5%

Solubility

Freely soluble in water, slightly soluble in ethanol and methylene chloride
Iron <10ppm
Chlorides <200ppm
Appearance of Solution Clear and colourless
Specific optical rotation -15.5 to -17.5
Total Impurities <2.5%
Ammonium <200ppm
Sulfated ash <0.1%
Sulphates <300ppm
Impurity E <0.5%

 

Post-translational protein modifications, such as tyrosine phosphorylation, regulate protein-protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an established yeast two-hybrid system employing human protein kinases for the analyses of phospho-tyrosine (pY)-dependent PPIs in a direct experimental, large-scale approach. We identified 292 mostly novel pY-dependent PPIs which showed high specificity with respect to kinases and interacting proteins and validated a large fraction in co-immunoprecipitation experiments from mammalian cells. About one-sixth of the interactions are mediated by known linear sequence binding motifs while the majority of pY-PPIs are mediated by other linear epitopes or governed by alternative recognition modes. Network analysis revealed that pY-mediated recognition events are tied to a highly connected protein module dedicated to signaling and cell growth pathways related to cancer. Using binding assays, protein compleme ntation and phenotypic readouts to characterize the pY-dependent interactions of TSPAN2 (tetraspanin 2) and GRB2 or PIK3R3 (p55γ), we exemplarily provide evidence that the two pY-dependent PPIs dictate cellular cancer phenotypes.


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    5 Stars By Lydia from Jordan - 2018.11.02 11:11
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    5 Stars By Matthew from Benin - 2018.10.31 10:02
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    OEM China Da - Glutathione reduced Cas: 70-18-8 98-101% Clear and colourless – XD BIOCHEM