o-Cresolphthalein Complexone CAS:2411-89-4 White powder
| Catalog Number | XD90463 |
| Product Name | o-Cresolphthalein Complexone |
| CAS | 2411-89-4 |
| Molecular Formula | C32H32N2O12 |
| Molecular Weight | 636.62 |
| Storage Details | Ambient |
| Harmonized Tariff Code | 2932209090 |
Product Specification
| Loss on Drying | 7.23% |
| Appearance | White powder |
| Assay | 99% |
| Storage Temperature | +20 ° C |
| Molecular Weight | 636.6 |
| Solubility | Clear purple solution |
| Residue on Ignition | 0.5% max |
| Nitrogen | 4.1-4.7% |
| Lambda max | 573nm in 0.1N sodium hydroxide |
| Lamda Max | 575(377)nm in 0.1 N sodium hydroxide |
| Carbon | 58-63% |
Bone morphogenetic proteins (BMPs) play a key role in bone and cartilage formation. For these properties, BMPs are employed in the field of tissue engineering to induce bone regeneration in damaged tissues. To overcome drawbacks due to the use of entire proteins, synthetic peptides derived from their parent BMPs have come out as promising molecules for biomaterial design. On the structural ground of the experimental BMP-2 receptor complexes reported in the literature, we designed three peptides, reproducing the BMP-2 region responsible for the binding to the type II receptor, ActRIIB. These peptides were characterized by NMR, and the structural features of the peptide-receptor binding interface were highlighted by docking experiments. Peptide-receptor binding affinities were analyzed by means of ELISA and surface plasmon resonance techniques. Furthermore, cellular assays were performed to assess their osteoinductive properties. A chimera peptide, obtained by combining the sequence port ions 73-92 and 30-34 of BMP-2, shows the best affinity for ActRIIB in the series and represents a good starting point for the design of new compounds able to reproduce osteogenic properties of the parent BMP-2.
