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Newly Arrival Pipes Sesquisodium Salt - 4-Fluoro-7-nitrobenzofurazan Cas: 29270-56-2 99% Solid – XD BIOCHEM

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Newly Arrival Pipes Sesquisodium Salt - 4-Fluoro-7-nitrobenzofurazan Cas: 29270-56-2 99% Solid – XD BIOCHEM Detail:

Catalog Number XD90223
Product Name 4-Fluoro-7-nitrobenzofurazan

CAS

29270-56-2

Molecular Formula

C6H2FN3O3

Molecular Weight

183.0968
Storage Details Under -20°C
Harmonized Tariff Code 2934999090

 

Product Specification

Appearance Solid
Assay 99%

 

Submillimolar concentrations of cytotoxic bile acids (BAs) induce cell death via apoptosis. On the other hand, several cytoprotective BAs were shown to prevent apoptosis in the same concentration range. Still, the mechanisms by which BAs trigger these opposite signaling effects remain unclear. This study was aimed to determine if cytotoxic and cytoprotective BAs, at physiologically active concentrations, are able to modulate the biophysical properties of lipid membranes, potentially translating into changes in the apoptotic threshold of cells. Binding of BAs to membranes was assessed through the variation of fluorescence parameters of suitable derivatized BAs. These derivatives partitioned with higher affinity to liquid disordered than to the cholesterol-enriched liquid ordered domains. Unlabeled BAs were also shown to have a superficial location upon interaction with the lipid membrane. Additionally, the interaction of cytotoxic BAs with membranes resulted in membrane expansion, as co ncluded from FRET data. Moreover, it was shown that cytotoxic BAs were able to significantly disrupt the ordering of the membrane by cholesterol at physiologically active concentrations of the BA, an effect not associated with cholesterol removal. On the other hand, cytoprotective bile acids had no effect on membrane properties. It was concluded that, given the observed effects on membrane rigidity, the apoptotic activity of cytotoxic BAs could be potentially associated with changes in plasma membrane organization (e.g. modulation of lipid domains) or with an increase in mitochondrial membrane affinity for apoptotic proteins.


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Newly Arrival Pipes Sesquisodium Salt - 4-Fluoro-7-nitrobenzofurazan Cas: 29270-56-2  99%  Solid – XD BIOCHEM detail pictures


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We are commitment to offer the competitive price ,outstanding products quality, as well as fast delivery for Newly Arrival Pipes Sesquisodium Salt - 4-Fluoro-7-nitrobenzofurazan Cas: 29270-56-2 99% Solid – XD BIOCHEM , The product will supply to all over the world, such as: Italy, Roman, Miami, Our tenet is "integrity first, quality best". We have confidence in providing you with excellent service and ideal products. We sincerely hope we can establish win-win business cooperation with you in the future!
  • Adhering to the business principle of mutual benefits, we have a happy and successful transaction, we think we will be the best business partner.
    5 Stars By Fanny from Kazakhstan - 2017.12.31 14:53
    Good quality, reasonable prices, rich variety and perfect after-sales service, it's nice!
    5 Stars By Edwina from Madras - 2017.11.12 12:31
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    Newly Arrival Pipes Sesquisodium Salt - 4-Fluoro-7-nitrobenzofurazan Cas: 29270-56-2 99% Solid – XD BIOCHEM