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N-Boc-D-serine is a derivative of D-serine that has a specific chemical modification, known as N-Boc (tert-butyloxycarbonyl) protection, attached to the amino group. This modification is commonly used in organic synthesis to protect the amino group and prevent undesirable reactions during chemical reactions. In the case of N-Boc-D-serine, this modification alters its properties and functions compared to the unmodified D-serine. Here are some of the key effects and applications of N-Boc-D-serine:Chemical Stability: The N-Boc protection makes N-Boc-D-serine more chemically stable than D-serine in certain conditions. This allows for easier handling, storage, and transportation of N-Boc-D-serine during chemical synthesis processes.Drug Development: N-Boc-D-serine and its derivatives are of interest in pharmaceutical research and drug development. They can be used as intermediates for the synthesis of various compounds, including D-amino acid-like molecules and N-methyl-D-aspartate (NMDA) receptor agonists or antagonists. The N-Boc protection on N-Boc-D-serine allows for specific chemical reactions, facilitating the synthesis of complex molecules with potential therapeutic applications.Peptide Synthesis: N-Boc-D-serine is commonly used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS). In SPPS, N-Boc-D-serine can be easily incorporated into peptide chains as a protected amino acid. The N-Boc group can then be selectively removed under specific conditions, allowing for the synthesis of long peptide sequences with N-Boc-D-serine residues.Chemical Biology Studies: N-Boc-D-serine and its derivatives have been used in chemical biology studies to investigate the roles and functions of D-serine in biological systems. These compounds can be used to selectively modulate D-serine levels and study its effects on various biological processes, including neuronal signaling, synaptic plasticity, and neurotransmission.Neurological Research: N-Boc-D-serine has also been used in neuroscience research to investigate the role of D-serine in neurological disorders, such as schizophrenia and Alzheimer's disease. By altering D-serine levels using N-Boc-D-serine and its derivatives, researchers can gain insights into the mechanisms underlying these disorders and potentially identify new therapeutic targets.In summary, N-Boc-D-serine is a chemically modified derivative of D-serine that has unique properties and applications. It offers increased chemical stability, making it suitable for use in drug development and peptide synthesis. Its use in chemical biology and neuroscience research further contributes to our understanding of the role of D-serine in biological processes and neurological disorders.