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N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly Cas:64967-39-1 99% White to off-white powder

Short Description:

Catalog Number: XD90187
Cas: 64967-39-1
Molecular Formula: C20H21N3O6
Molecular Weight: 399.39
Availability: In Stock
Price:  
Prepack: 1g USD30
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Product Detail

Product Tags

Catalog Number XD90187
Product Name N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly
CAS 64967-39-1
Molecular Formula C20H21N3O6
Molecular Weight 399.39
Storage Details -15 to -20 °C
Harmonized Tariff Code 29321900

 

Product Specification

Appearance White to off-white powder
Assay ≥99%
Melting point 245 °C (dec.)(lit.)
Solubility NH4OH 1 M: 50 mg/mL, clear to slightly turbid, yellow

PSA 137.74000

 

In the kinetic angiotensin-converting enzyme (ACE) method, a practical and optimal buffer is 80 mmol/L borate buffer at pH 8.2 (37 degrees C). A lag phase is detected in the reaction, and a 5-min incubation of substrate and plasma is suggested before the kinetic measurement. The substrate, N-[3-(2-furyl)acryloyl]-L-phenylalanylglycylglycine (FAPGG), concentration is maximized at 1.0 mmol/L and the measurement wavelength is at 345 nm to ensure linearity of measurement. The proposed procedure uses a 1:9 plasma-to-reagent volume ratio. The linear range of the assay extends to approximately 170 U/L, representing a 25% substrate hydrolysis. The FAPGG absorptivity is determined by measuring the difference in absorbance between 1.0 mmol/L FAPGG and the product solutions. The wavelength fidelity is checked by noting the expected absorbance value of the FAPGG solution, and a 1.0-nm deviation from 345 nm alters the absorbance by 15.5%. The precision of ACE assays at approximately 60 and 100 U/L is 3.5% and 2.4% within batch and 2.9% and 2.6% between batch, respectively. The reference interval (2.5th to 97.5th percentiles) is 41-139 U/L, and there is no difference between values for men and women.


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    N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly Cas:64967-39-1 99% White to off-white powder