page_banner

Products

N-(2-Aminoethyl) morpholine Cas:2038-03-1 99% Colorless to yellow liquid

Short Description:

Catalog Number: XD90061
Cas: 2038-03-1
Molecular Formula: C6H14N2O
Molecular Weight: 130.19
Availability: In Stock
Price:
Prepack: 25ML USD10
Bulk Pack: Request Quote

Product Detail

Product Tags

Catalog Number XD90061
Product Name N-(2-Aminoethyl)morpholine
CAS 2038-03-1
Molecular Formula C6H14N2O
Molecular Weight 130.19
Storage Details Ambient

Product Specification

Appearance Colorless to yellow liquid
Assay 99% min
Storage Temp Store at RT
Density 0.992 g/mL at 25 C(lit.)
Refractive index n20/D 1.476(lit.)
Water solubility Soluble
Vapor pressure 0.289mmHg at 25 C

Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.

The secretory isozyme of human carbonic anhydrase (hCA, EC 4.2.1.1), hCA VI, has been cloned, expressed, and purified in a bacterial expression system. The kinetic parameters for the CO(2) hydration reaction proved hCA VI to possess a k(cat) of 3.4 x 10(5)s(-1) and k(cat)/K(M) of 4.9 x 10(7)M(-1)s(-1) (at pH 7.5 and 20 degrees C). hCA VI has a significant catalytic activity for the physiological reaction, of the same order of magnitude as the ubiquitous isoform CA I or the transmembrane, tumor-associated isozyme CA IX. A series of amino acids and amines were shown to act as CA VI activators, with variable efficacies. l-His, l-Trp, and dopamine showed weak CA VI activating effects (K(A)s in the range of 21-42 microM), whereas d-His, d-Phe, l-DOPA, l-Trp, serotonin, and some pyridyl-alkylamines were better activators, with K(A)s in the range of 13-19 microM. The best CA VI activators were l-Phe, d-DOPA, l-Tyr, 4-amino-l-Phe, and histamine, with K(A)s in the range of 1.23-9.31 microM. All these activators enhance k(cat), having no effect on K(M), participating thus in the rate determining step in the catalytic cycle, the proton transfer reactions between the enzyme active site and the environment.


  • Previous:
  • Next:

  • Close

    N-(2-Aminoethyl) morpholine Cas:2038-03-1 99% Colorless to yellow liquid