Manufacturing Companies for Rituxan - D-Valine Cas: 640-68-6 C5H11NO2 – XD BIOCHEM
Manufacturing Companies for Rituxan - D-Valine Cas: 640-68-6 C5H11NO2 – XD BIOCHEM Detail:
Catalog Number | XD90291 |
Product Name | D-Valine |
CAS |
640-68-6 |
Molecular Formula |
C5H11NO2 |
Molecular Weight |
117.14634 |
Storage Details | Room Temp |
Harmonized Tariff Code |
29224995 |
Product Specification
Assay | 99% |
Appearance | White powder |
Density | 1.2000 (estimate) |
Melting point | >295 °C (subl.) (lit.) |
Boiling point | 213.6 °C at 760 mmHg |
Flash point | 83℃ |
Refractive index | -27 ° (C=8, 6mol/L HCl) |
Solubility | 56 g/L (20°C) |
Water solubility | 56 g/L (20 ºC) |
PSA | 63.32000 |
LogP | 0.75460 |
Specific rotation | -27.5 º (c=5, 5N HCl) |
Optical activity | [α]23/D −32.0 to −24.0°, c = 8 in 6 M HCl |
Women with antiphospholipid syndrome (APS) are at increased risk of recurrent pregnancy loss (RPL) and preeclampsia. Antiphospholipid antibodies (aPL) directly alter trophoblast function. Treatment with low molecular weight heparin (LMWH) reduces the risk of RPL but not preeclampsia. Moreover, LMWH stimulates trophoblast sFlt-1 release, an anti-angiogenic factor associated with preeclampsia. Since vitamin D deficiency is associated with APS and preeclampsia, this study sought to determine the effect of vitamin D on trophoblast function in the setting of aPL and LMWH.A human first trimester trophoblast cell line (HTR8) and primary trophoblast cultures were treated with or without aPL in the presence and absence of vitamin D, LMWH or both. Trophoblast secretion of inflammatory cytokines and angiogenic factors were measured by ELISA.Vitamin D alone or in combination with LMWH attenuated the aPL-induced trophoblast inflammatory response in the HTR8 cells and primary cultures. While vitamin D did not have any impact on aPL-mediated modulation of angiogenic factors in the primary trophoblast, it significantly inhibited LMWH-induced sFlt-1 release.LMWH in combination with vitamin D may be more beneficial than single-agent therapy by preventing aPL-induced trophoblast inflammation and reversing LMWH-induced sFlt-1 secretion.
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We take "customer-friendly, quality-oriented, integrative, innovative" as objectives. "Truth and honesty" is our administration ideal for Manufacturing Companies for Rituxan - D-Valine Cas: 640-68-6 C5H11NO2 – XD BIOCHEM , The product will supply to all over the world, such as: Azerbaijan, Eindhoven, Kenya, With a wide range, good quality, reasonable prices and stylish designs, our products are extensively used in public placesand other industries. Our products are widely recognized and trusted by users and can meet continuously developing economic and social needs. We welcome new and old customers from all walks of life to contact us for future business relationships and achieving mutual success!
By Sara from Mozambique - 2017.07.07 13:00
Adhering to the business principle of mutual benefits, we have a happy and successful transaction, we think we will be the best business partner.
By Esther from Afghanistan - 2018.09.08 17:09