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Iodonitrotetrazolium chloride CAS:146-68-9

Short Description:

Catalog Number: XD90473
CAS: 146-68-9
Molecular Formula: C19H13ClIN5O2
Molecular Weight: 505.70
Availability: In Stock
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Prepack: 1g USD20
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Product Detail

Product Tags

Catalog Number XD90473
Product Name Iodonitrotetrazolium chloride
CAS 146-68-9
Molecular Formula C19H13ClIN5O2
Molecular Weight 505.70
Storage Details 2 to 8 °C
Harmonized Tariff Code 32129000

 

Product Specification

Identification H-NMR
Appearance Light yellow to orange powder
Assay >99%
Solubility Clear solution

 

Interferon-induced transmembrane protein 1 (IFITM1) is one of the interferon-induced transmembrane protein family members. In this study, we reported that the elevated IFITM1 expression in human colorectal cancer (CRC) significantly correlated with CRC lymph node and distance metastasis as well as a more advanced clinical stage. Importantly, elevated IFITM1 expression is an independent prognostic factor for poor survival. To investigate the molecular mechanisms, we showed that over-expression of IFITM1 in CRC cells promoted, whereas knockdown of IFITM1 expression inhibited, cell migration/invasion and tumorigenicity in vitro. Furthermore, we identified Caveolin-1 (CAV1) as a downstream target of IFITM1-induced cell invasion, as knockdown of CAV1 abrogated siIFITM1 mediated inhibition of cell invasion in CRC cells. In addition, in a CRC cohort of 229 patients, the expression of IFITM1 inversely correlated with the expression of CAV1. These results suggested that IFITM1 promotes the aggr essiveness of CRC cells, and it is a potential prognostic marker and therapeutic target for CRC.


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    Iodonitrotetrazolium chloride CAS:146-68-9