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Hoechst 33258 Cas: 23491-45-4 Pale yellow crystalline powder

Short Description:

Catalog Number: XD90536
Cas: 23491-45-4
Molecular Formula: C25H24N6O·3(HCl)
Molecular Weight: 533.88
Availability: In Stock
Price:  
Prepack: 100mg USD10
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Product Detail

Product Tags

Catalog Number XD90536
Product Name Hoechst 33258

CAS

23491-45-4

Molecular Formula

C25H24N6O·3(HCl)

Molecular Weight

533.88
Storage Details -15 to -20 °C
Harmonized Tariff Code 32129000

 

Product Specification

Appearance

Pale yellow crystalline powder

Assay

99%

 

Interaction between antidiabetic drug, Metformin and calf thymus DNA (CT-DNA) in (50mM Tris-HCl) buffer were studied by UV-Visible absorption, fluorescence, CD spectroscopy and viscosity measurements. In fluorimetric studies, the enthalpy and entropy of the reaction between the drug and CT-DNA showed that the reaction is exothermic (ΔH=-35.4522 kJ mol(-1); ΔS=-49.9523 J mol(-1)K(-1)). The competitive binding studies showed that the drug could release Hoechst 33258 completely. The complex showed absorption hyperchromism in its UV-Vis spectrum with DNA. The calculated binding constant, K(b), obtained from UV-Vis absorption studies was 8.3×10(4)M(-1). Moreover, the changes in the CD spectra in the presence of the drug show stabilization of the right-handed B form of CT-DNA. Finally, viscosity measurements revealed that the binding of the complex with CT-DNA could be surface binding, mainly due to groove binding.Copyright © 2012 Elsevier B.V. All rights reserved.


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    Hoechst 33258 Cas: 23491-45-4 Pale yellow crystalline powder