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High Quality for 3-Nitrophenyl-Beta-D-Galactopyranoside - 3-(N,N-dimethyldodecylammonio) propanesulfonate Cas:14933-08-5 99% – XD BIOCHEM

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Our purpose would be to offer good quality products at competitive price ranges, and top-notch support to clients around the whole world. We're ISO9001, CE, and GS certified and strictly adhere to their good quality specifications for Enzyme Catalysis, Pd-L1 Mab Atezolizumab, Phenylgalactoside, Our Lab now is "National Lab of diesel engine turbo technology " , and we own a professional R&D team and complete testing facility.
High Quality for 3-Nitrophenyl-Beta-D-Galactopyranoside - 3-(N,N-dimethyldodecylammonio) propanesulfonate Cas:14933-08-5 99% – XD BIOCHEM Detail:

Catalog Number XD90062
Product Name 3-(N,N-dimethyldodecylammonio) propanesulfonate
CAS 14933-08-5
Molecular Formula C17H35NO5S
Molecular Weight 335.55
Storage Details Ambient
Harmonized Tariff Code 29239000

Product Specification

Appearance White powder
Assay 99% min
Storage Temp +20 ° C

Effects of detergents on P-glycoprotein atpase activity: differences in perturbations of basal and verapamil-dependent activities.

P-glycoprotein (P-gp), a plasma membrane glycoprotein associated with the multidrug resistance phenotype, is responsible for the ATP-dependent efflux of various amphiphilic drugs. Using membrane vesicles prepared from the multidrug resistant cell line DC-3F/ADX, we studied the perturbation of the basal (i.e. in the absence of drug) and verapamil-dependent P-gp ATPase activities induced by various detergents, at non-solubilizing, as well as at solubilizing, concentrations. The progressive membrane solubilization with increasing detergent concentration was monitored by light scattering and centrifugation experiments. For non-solubilizing detergent concentrations, all tested detergents except DOC induced a partial inhibition of P-gp ATPase activity, which was not correlated with the amount of the various tested detergents incorporated in the membranes. Analysis of the verapamil-induced P-gp activation reveals that P-gp ATPase activity is differently modulated by the various detergents at non-solubilizing concentrations. Thus, specific interactions between P-gp and detergents are more likely to occur rather than a global membrane perturbation. After solubilization by the various tested detergents, the basal P-gp ATPase activity was virtually completely inhibited, except in the presence of CHAPS which was able to preserve this activity at a level comparable to that measured in native membranes. However, the verapamil-induced P-gp ATPase activation was lost during P-gp solubilization by CHAPS, but recovered after dilution of CHAPS below its critical micellar concentration. These observations indicate specific interactions between P-gp and CHAPS molecules within the mixed micelles. On the whole, our data evidencing specific interactions P-gp/detergents are consistent with the location of the drug transport sites on P-gp transmembrane domains.


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Our workforce through professional training. Skilled professional knowledge, solid sense of service, to fulfill the services demands of consumers for High Quality for 3-Nitrophenyl-Beta-D-Galactopyranoside - 3-(N,N-dimethyldodecylammonio) propanesulfonate Cas:14933-08-5 99% – XD BIOCHEM , The product will supply to all over the world, such as: Juventus, Finland, Florida, With its rich manufacturing experience, high-quality products, and perfect after-sale service, the company has gained good reputation and has become one of the famous enterprise specialized in manufacturing series.We sincerely hope to establish business relation with you and pursue mutual benefit.
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    5 Stars By Dana from Salt Lake City - 2017.10.25 15:53
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    High Quality for 3-Nitrophenyl-Beta-D-Galactopyranoside - 3-(N,N-dimethyldodecylammonio) propanesulfonate Cas:14933-08-5 99% – XD BIOCHEM