page_banner

Products

Good User Reputation for Ada Disodium Salt - Iodonitrotetrazolium chloride Cas: 146-68-9 98% Light yellow to orange powder – XD BIOCHEM

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

Our growth depends around the superior machines, exceptional talents and consistently strengthened technology forces for Reference Compounds, Hdaos, Patented Drug, Should further information be required, please contact us at any time!
Good User Reputation for Ada Disodium Salt - Iodonitrotetrazolium chloride Cas: 146-68-9 98% Light yellow to orange powder – XD BIOCHEM Detail:

Catalog Number XD90217
Product Name Iodonitrotetrazolium chloride

CAS

146-68-9

Molecular Formula

C19H13ClIN5O2

Molecular Weight

505.70
Storage Details 2 to 8 °C
Harmonized Tariff Code 32129000

 

Product Specification

Identification H-NMR
Solubility Clear solution
Appearance Light yellow to orange powder
Assay HPLC >98%

 

A reciprocal translocation of the ABL1 gene to the BCR gene results in the expression of the oncogenic BCR-ABL1 fusion protein, which characterizes human chronic myeloid leukemia (CML), a myeloproliferative disorder considered invariably fatal until the introduction of the imatinib family of tyrosine kinase inhibitors (TKI). Nonetheless, insensitivity of CML stem cells to TKI treatment and intrinsic or acquired resistance are still frequent causes for disease persistence and blastic phase progression experienced in patients after initial successful therapies. Here, we investigated a possible role for the MAPK15/ERK8 kinase in BCR-ABL1-dependent autophagy, a key process for oncogene-induced leukemogenesis. In this context, we showed the ability of MAPK15 to physically recruit the oncogene to autophagic vesicles, confirming our hypothesis of a biologically relevant role for this MAP kinase in signal transduction by this oncogene. Indeed, by modeling BCR-ABL1 signaling in HeLa cells and t aking advantage of a physiologically relevant model for human CML, i.e. K562 cells, we demonstrated that BCR-ABL1-induced autophagy is mediated by MAPK15 through its ability to interact with LC3-family proteins, in a LIR-dependent manner. Interestingly, we were also able to interfere with BCR-ABL1-induced autophagy by a pharmacological approach aimed at inhibiting MAPK15, opening the possibility of acting on this kinase to affect autophagy and diseases depending on this cellular function. Indeed, to support the feasibility of this approach, we demonstrated that depletion of endogenous MAPK15 expression inhibited BCR-ABL1-dependent cell proliferation, in vitro, and tumor formation, in vivo, therefore providing a novel “druggable” link between BCR-ABL1 and human CML.


Product detail pictures:

Good User Reputation for Ada Disodium Salt - Iodonitrotetrazolium chloride  Cas: 146-68-9  98%  Light yellow to orange powder – XD BIOCHEM detail pictures


Related Product Guide:

Our mission should be to turn out to be an innovative supplier of high-tech digital and communication devices by furnishing benefit added design and style, world-class manufacturing, and repair capabilities for Good User Reputation for Ada Disodium Salt - Iodonitrotetrazolium chloride Cas: 146-68-9 98% Light yellow to orange powder – XD BIOCHEM , The product will supply to all over the world, such as: Turkey, Lithuania, Hamburg, By integrating manufacturing with foreign trade sectors, we can provide total customer solutions by guaranteeing the delivery of right products to the right place at the right time, which is supported by our abundant experiences, powerful production capability, consistent quality, diversified products and the control of the industry trend as well as our maturity before and after sales services. We'd like to share our ideas with you and welcome your comments and questions.
  • This company conforms to the market requirement and joins in the market competition by its high quality product, this is an enterprise that have Chinese spirit.
    5 Stars By Riva from Spain - 2018.09.29 17:23
    High Quality, High Efficiency, Creative and Integrity, worth having long-term cooperation! Looking forward to the future cooperation!
    5 Stars By Sophia from USA - 2017.08.16 13:39
    Close

    Good User Reputation for Ada Disodium Salt - Iodonitrotetrazolium chloride Cas: 146-68-9 98% Light yellow to orange powder – XD BIOCHEM