Free sample for Pharmacy Company - Glutathione oxidized Cas: 27025-41-8 White crystalline powder – XD BIOCHEM
Free sample for Pharmacy Company - Glutathione oxidized Cas: 27025-41-8 White crystalline powder – XD BIOCHEM Detail:
Catalog Number | XD90283 |
Product Name | Glutathione oxidized |
CAS |
27025-41-8 |
Molecular Formula |
C20H32N6O12S2 |
Molecular Weight |
612.63 |
Storage Details | 2 to 8 °C |
Harmonized Tariff Code |
2930909899 |
Product Specification
Assay | 99% |
Appearance | White crystalline powder |
Specific rotation | -96 to -106 |
Heavy metals | 10ppm max |
AS | 2ppm max |
Loss on Drying | 15.0% max. |
Purity | 95% min |
Residue on Ignition | 0.5% max |
Hepatotoxicity of drug candidates is one of the major concerns in drug screening in early drug discovery. Detection of hepatic oxidative stress can be an early indicator of hepatotoxicity and benefits drug selection. The glutathione (GSH) and glutathione disulfide (GSSG) pair, as one of the major intracellular redox regulating couples, plays an important role in protecting cells from oxidative stress that is caused by imbalance between prooxidants and antioxidants. The quantitative determination of the GSSG/GSH ratios and the concentrations of GSH and GSSG have been used to indicate oxidative stress in cells and tissues. In this study, we tested the possibility of using the biliary GSSG/GSH ratios as a biomarker to reflect hepatic oxidative stress and drug toxicity. Four compounds that are known to alter GSH and GSSG levels were tested in this study. Diquat (diquat dibromide monohydrate) and acetaminophen were administered to rats. Paraquat and tert-butyl hydroperoxide were administere d to mice to induce changes of biliary GSH and GSSG. The biliary GSH and GSSG were quantified using calibration curves prepared with artificial bile to account for any bile matrix effect in the LC-MS analysis and to avoid the interference of endogenous GSH and GSSG. With four examples (in rats and mice) of drug-induced changes in the kinetics of the biliary GSSG/GSH ratios, this study showed the potential for developing an exposure response index based on biliary GSSG/GSH ratios for predicting hepatic oxidative stress.
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Our target is to consolidate and improve the quality and service of existing products, meanwhile constantly develop new products to meet different customers' demands for Free sample for Pharmacy Company - Glutathione oxidized Cas: 27025-41-8 White crystalline powder – XD BIOCHEM , The product will supply to all over the world, such as: Malta, Amman, Rome, For more than ten years experience in this filed, our company has gained high reputation from home and abroad. So we welcome friends from all over the world to come and contact us, not only for business, but also for friendship.
By Rachel from Portugal - 2018.09.29 13:24
Product variety is complete, good quality and inexpensive, the delivery is fast and transport is security, very good, we are happy to cooperate with a reputable company!
By Aurora from Mongolia - 2018.06.03 10:17