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Fmoc-O-tert-butyl-L-threonine, also known as Fmoc-OtBu-L-threonine, is a derivative of L-threonine commonly used in peptide synthesis and solid-phase peptide synthesis (SPPS). It is a protected form of L-threonine with the Fmoc (9-fluorenylmethyloxycarbonyl) group attached to the hydroxyl group of the threonine residue, and the tert-butyl (tBu) group protecting the amino group.One of the main effects of Fmoc-OtBu-L-threonine is its incorporation into peptide chains. Peptides are composed of amino acids linked together through peptide bonds, and Fmoc-OtBu-L-threonine serves as a building block in this process. By introducing Fmoc-OtBu-L-threonine into the peptide sequence, researchers can incorporate the threonine residue at desired positions and study the effects of threonine on peptide structure and function.Another important function of Fmoc-OtBu-L-threonine is the protection of both the amino and hydroxyl groups of threonine. The Fmoc group shields the amino group, preventing unwanted reactions during peptide synthesis. Additionally, the tert-butyl ester group protects the hydroxyl group from potential side reactions, ensuring the controlled and selective formation of peptide bonds. This protection allows for efficient and precise peptide synthesis.Fmoc-OtBu-L-threonine also plays a role in enhancing peptide stability and bioactivity. Threonine is an amino acid that is involved in many important biological processes, including protein folding, enzyme catalysis, and post-translational modifications. By incorporating Fmoc-OtBu-L-threonine into peptide structures, researchers can mimic the role of threonine and study its influence on peptide structure and function.Furthermore, Fmoc-OtBu-L-threonine can be used in the synthesis of peptide analogs and peptide libraries. Peptide analogs are modified versions of peptides that mimic the structure and function of natural peptides but offer improved stability or bioactivity. Fmoc-OtBu-L-threonine can be utilized to introduce specific modifications or functional groups into peptide analogs, allowing for the exploration of new therapeutic targets and drug candidates.In summary, Fmoc-O-tert-butyl-L-threonine is a valuable compound in peptide synthesis and SPPS. It enables the controlled incorporation of threonine residues into peptide sequences while providing protection to the amino and hydroxyl groups. Fmoc-OtBu-L-threonine plays a crucial role in peptide synthesis, structural modification, and the development of peptide-based therapeutics or tools for studying the functions of threonine-rich peptides.