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Fast green  Cas: 2353-45-9 Red to brown powder

Short Description:

Catalog Number: XD90527
Cas: 2353-45-9
Molecular Formula: C37H34N2Na2O10S3
Molecular Weight: 808.85
Availability: In Stock
Price:  
Prepack: 25g USD10
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Product Detail

Product Tags

Catalog Number XD90527
Product Name Fast green

CAS

2353-45-9

Molecular Formula

C37H34N2Na2O10S3

Molecular Weight

808.85
Storage Details Ambient
Harmonized Tariff Code 32129000

 

Product Specification

Appearance

Red to brown powder

Assay

≥99%

Water-insoluble matter

≤0.20%

 

Chronic airway inflammation and remodeling, including fibrosis, have been proposed as important contributors to asthma pathophysiology. Previous studies of airway fibrosis have been performed mainly in mild and moderate asthmatics at the subepithelial "basement membrane" (SBM) level. The current study was designed to evaluate the large airway SBM thickness and submucosal collagen deposition, as measured by three different collagen staining methods, in endobronchial biopsies from 17 severe, nine moderate, and seven mild asthmatics, as well as eight normal control subjects. Tissue eosinophils and transforming growth factor-beta (TGF-beta) immunoreactivity were also examined. There were no statistically significant differences in the SBM thickness, submucosal collagen deposition, eosinophil numbers, or TGF-beta positive cells among the three groups of asthmatics and the normal control subjects. It was only when examining all asthmatics (n = 33) together, that a modestly thickened SBM (p = 0.04), as evaluated by collagen type III immunostaining, was observed as compared with normal control subjects. Despite this difference, no significant differences were found in the amount of submucosal collagen deposition and the number of eosinophils or TGF-beta expressing cells when comparing total asthmatics and normal control subjects. Additionally, no significant correlations were found between collagen deposition and eosinophil count, TGF-beta expression level, FEV1, or duration of asthma. These results suggest that although increased collagen deposition in the SBM at the large airway level is a characteristic of asthma, it may not explain the differences in severity of asthma.


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    Fast green  Cas: 2353-45-9 Red to brown powder