page_banner

Products

Factory wholesale Abts Reagents - Glutathione oxidized Cas: 27025-41-8 White crystalline powder – XD BIOCHEM

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

We have been ready to share our knowledge of advertising worldwide and recommend you suitable products at most aggressive costs. So Profi Tools present you ideal price of money and we've been ready to create with each other with 126-11-4, Phenylgalactoside, 115-69-5, We will supply best quality, the most market competitive price, for every new and old customers with the most perfect green services.
Factory wholesale Abts Reagents - Glutathione oxidized Cas: 27025-41-8 White crystalline powder – XD BIOCHEM Detail:

Catalog Number XD90283
Product Name Glutathione oxidized

CAS

27025-41-8

Molecular Formula

C20H32N6O12S2

Molecular Weight

612.63
Storage Details 2 to 8 °C

Harmonized Tariff Code

2930909899

 

Product Specification

Assay 99%
Appearance White crystalline powder
Specific rotation -96 to -106
Heavy metals 10ppm max
AS 2ppm max
Loss on Drying 15.0% max.
Purity 95% min
Residue on Ignition 0.5% max

Hepatotoxicity of drug candidates is one of the major concerns in drug screening in early drug discovery. Detection of hepatic oxidative stress can be an early indicator of hepatotoxicity and benefits drug selection. The glutathione (GSH) and glutathione disulfide (GSSG) pair, as one of the major intracellular redox regulating couples, plays an important role in protecting cells from oxidative stress that is caused by imbalance between prooxidants and antioxidants. The quantitative determination of the GSSG/GSH ratios and the concentrations of GSH and GSSG have been used to indicate oxidative stress in cells and tissues. In this study, we tested the possibility of using the biliary GSSG/GSH ratios as a biomarker to reflect hepatic oxidative stress and drug toxicity. Four compounds that are known to alter GSH and GSSG levels were tested in this study. Diquat (diquat dibromide monohydrate) and acetaminophen were administered to rats. Paraquat and tert-butyl hydroperoxide were administere d to mice to induce changes of biliary GSH and GSSG. The biliary GSH and GSSG were quantified using calibration curves prepared with artificial bile to account for any bile matrix effect in the LC-MS analysis and to avoid the interference of endogenous GSH and GSSG. With four examples (in rats and mice) of drug-induced changes in the kinetics of the biliary GSSG/GSH ratios, this study showed the potential for developing an exposure response index based on biliary GSSG/GSH ratios for predicting hepatic oxidative stress.


Product detail pictures:

Factory wholesale Abts Reagents - Glutathione oxidized  Cas: 27025-41-8  White crystalline powder – XD BIOCHEM detail pictures


Related Product Guide:

We will make just about every exertion for being excellent and perfect, and speed up our actions for standing during the rank of worldwide top-grade and high-tech enterprises for Factory wholesale Abts Reagents - Glutathione oxidized Cas: 27025-41-8 White crystalline powder – XD BIOCHEM , The product will supply to all over the world, such as: Italy, Croatia, Japan, Our company is an international supplier on this kind of merchandise. We supply an amazing selection of high-quality merchandise. Our goal is to delight you with our distinctive collection of mindful items while providing value and excellent service. Our mission is simple: To supply the best items and service to our customers at the lowest prices possible.
  • The after-sale warranty service is timely and thoughtful, encounter problems can be resolved very quickly, we feel reliable and secure.
    5 Stars By Pag from Jeddah - 2017.08.18 11:04
    Although we are a small company, we are also respected. Reliable quality, sincere service and good credit, we are honored to be able to work with you!
    5 Stars By Judith from Russia - 2017.01.11 17:15
    Close

    Factory wholesale Abts Reagents - Glutathione oxidized Cas: 27025-41-8 White crystalline powder – XD BIOCHEM