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Factory source Pharmaceutical Manager - Glutathione oxidized Cas: 27025-41-8 White crystalline powder – XD BIOCHEM

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Factory source Pharmaceutical Manager - Glutathione oxidized Cas: 27025-41-8 White crystalline powder – XD BIOCHEM Detail:

Catalog Number XD90283
Product Name Glutathione oxidized

CAS

27025-41-8

Molecular Formula

C20H32N6O12S2

Molecular Weight

612.63
Storage Details 2 to 8 °C

Harmonized Tariff Code

2930909899

 

Product Specification

Assay 99%
Appearance White crystalline powder
Specific rotation -96 to -106
Heavy metals 10ppm max
AS 2ppm max
Loss on Drying 15.0% max.
Purity 95% min
Residue on Ignition 0.5% max

Hepatotoxicity of drug candidates is one of the major concerns in drug screening in early drug discovery. Detection of hepatic oxidative stress can be an early indicator of hepatotoxicity and benefits drug selection. The glutathione (GSH) and glutathione disulfide (GSSG) pair, as one of the major intracellular redox regulating couples, plays an important role in protecting cells from oxidative stress that is caused by imbalance between prooxidants and antioxidants. The quantitative determination of the GSSG/GSH ratios and the concentrations of GSH and GSSG have been used to indicate oxidative stress in cells and tissues. In this study, we tested the possibility of using the biliary GSSG/GSH ratios as a biomarker to reflect hepatic oxidative stress and drug toxicity. Four compounds that are known to alter GSH and GSSG levels were tested in this study. Diquat (diquat dibromide monohydrate) and acetaminophen were administered to rats. Paraquat and tert-butyl hydroperoxide were administere d to mice to induce changes of biliary GSH and GSSG. The biliary GSH and GSSG were quantified using calibration curves prepared with artificial bile to account for any bile matrix effect in the LC-MS analysis and to avoid the interference of endogenous GSH and GSSG. With four examples (in rats and mice) of drug-induced changes in the kinetics of the biliary GSSG/GSH ratios, this study showed the potential for developing an exposure response index based on biliary GSSG/GSH ratios for predicting hepatic oxidative stress.


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    Factory source Pharmaceutical Manager - Glutathione oxidized Cas: 27025-41-8 White crystalline powder – XD BIOCHEM