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Factory Price For Patented Drug - Poly-L-lysine solution ( 0.1%) Cas: 25988-63-0 – XD BIOCHEM

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Factory Price For Patented Drug - Poly-L-lysine solution ( 0.1%) Cas: 25988-63-0 – XD BIOCHEM Detail:

Catalog Number XD90306
Product Name Poly-L-lysine solution ( 0.1%)

CAS

25988-63-0

Molecular Formula

C18H38N6O4

Molecular Weight

402.532124042511
Storage Details 2-8°C

 

Product Specification

Assay 0.1%
Appearance Colorless liquid

 

eucine-rich repeat kinase 2 (LRRK2) mutations are the most common known cause of Parkinson’s disease (PD). The clinical features of LRRK2 PD are indistinguishable from idiopathic PD, with accumulation of α-synuclein and/or tau and/or ubiquitin in intraneuronal aggregates. This suggests that LRRK2 is a key to understanding the aetiology of the disorder. Although loss-of-function does not appear to be the mechanism causing PD in LRRK2 patients, it is not clear how this protein mediates toxicity. In this study, we report that LRRK2 overexpression in cells and in vivo impairs the activity of the ubiquitin-proteasome pathway, and that this accounts for the accumulation of diverse substrates with LRRK2 overexpression. We show that this is not mediated by large LRRK2 aggregates or sequestration of ubiquitin to the aggregates. Importantly, such abnormalities are not seen with overexpression of the related protein LRRK1. Our data suggest that LRRK2 inhibits the clearance of proteasome substrate s upstream of proteasome catalytic activity, favouring the accumulation of proteins and aggregate formation. Thus, we provide a molecular link between LRRK2, the most common known cause of PD, and its previously described phenotype of protein accumulation.


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    Factory Price For Patented Drug - Poly-L-lysine solution ( 0.1%) Cas: 25988-63-0 – XD BIOCHEM