Factory Price For Patented Drug - Glutathione oxidized Cas: 27025-41-8 White crystalline powder – XD BIOCHEM
Factory Price For Patented Drug - Glutathione oxidized Cas: 27025-41-8 White crystalline powder – XD BIOCHEM Detail:
Catalog Number | XD90283 |
Product Name | Glutathione oxidized |
CAS |
27025-41-8 |
Molecular Formula |
C20H32N6O12S2 |
Molecular Weight |
612.63 |
Storage Details | 2 to 8 °C |
Harmonized Tariff Code |
2930909899 |
Product Specification
Assay | 99% |
Appearance | White crystalline powder |
Specific rotation | -96 to -106 |
Heavy metals | 10ppm max |
AS | 2ppm max |
Loss on Drying | 15.0% max. |
Purity | 95% min |
Residue on Ignition | 0.5% max |
Hepatotoxicity of drug candidates is one of the major concerns in drug screening in early drug discovery. Detection of hepatic oxidative stress can be an early indicator of hepatotoxicity and benefits drug selection. The glutathione (GSH) and glutathione disulfide (GSSG) pair, as one of the major intracellular redox regulating couples, plays an important role in protecting cells from oxidative stress that is caused by imbalance between prooxidants and antioxidants. The quantitative determination of the GSSG/GSH ratios and the concentrations of GSH and GSSG have been used to indicate oxidative stress in cells and tissues. In this study, we tested the possibility of using the biliary GSSG/GSH ratios as a biomarker to reflect hepatic oxidative stress and drug toxicity. Four compounds that are known to alter GSH and GSSG levels were tested in this study. Diquat (diquat dibromide monohydrate) and acetaminophen were administered to rats. Paraquat and tert-butyl hydroperoxide were administere d to mice to induce changes of biliary GSH and GSSG. The biliary GSH and GSSG were quantified using calibration curves prepared with artificial bile to account for any bile matrix effect in the LC-MS analysis and to avoid the interference of endogenous GSH and GSSG. With four examples (in rats and mice) of drug-induced changes in the kinetics of the biliary GSSG/GSH ratios, this study showed the potential for developing an exposure response index based on biliary GSSG/GSH ratios for predicting hepatic oxidative stress.
Product detail pictures:
Related Product Guide:
The corporation upholds the philosophy of "Be No.1 in excellent, be rooted on credit rating and trustworthiness for growth", will proceed to provide aged and new buyers from home and abroad whole-heatedly for Factory Price For Patented Drug - Glutathione oxidized Cas: 27025-41-8 White crystalline powder – XD BIOCHEM , The product will supply to all over the world, such as: Botswana, Greek, Jakarta, We solution have passed through the national skilled certification and been well received in our key industry. Our specialist engineering team will often be ready to serve you for consultation and feedback. We've been able to also provide you with no cost samples to meet your needs. Best efforts are going to be produced to supply you the very best service and solutions. For anyone who is considering our business and solutions, please speak to us by sending us emails or get in touch with us right away. As a way to know our items and enterprise. lot more, you'll be able to come to our factory to find out it. We'll constantly welcome guests from around the globe to our firm. o build enterprise. elations with us. You should really feel absolutely free to make contact with us for small business and we believe we'll share the top trading practical experience with all our merchants.
By Amy from Monaco - 2018.12.25 12:43
It is not easy to find such a professional and responsible provider in today's time. Hope that we can maintain long-term cooperation.
By Elaine from Malaysia - 2017.02.28 14:19