Factory Outlets Pd-L1 Mab Bavencio - DL-Alanine CAS:302-72-7 99% – XD BIOCHEM
Factory Outlets Pd-L1 Mab Bavencio - DL-Alanine CAS:302-72-7 99% – XD BIOCHEM Detail:
| Catalog Number | XD90327 |
| Product Name | DL-Alanine |
| CAS | 302-72-7 |
| Molecular Formula | C3H7NO2 |
| Molecular Weight | 89.09 |
| Storage Details | Ambient |
| Harmonized Tariff Code | 29224985 |
Product Specification
| Catalog Number | XD90327 |
| Product Name | DL-Alanine |
| CAS | 302-72-7 |
| Molecular Formula | C3H7NO2 |
| Molecular Weight | 89.09 |
| Storage Details | Ambient |
| Harmonized Tariff Code | 29224985 |
The effectiveness of antibiotic molecules in treating Pseudomonas aeruginosa pneumonia is reduced as a result of the dissemination of bacterial resistance. The existence of bacterial communication systems, such as quorum sensing, has provided new opportunities of treatment. Lactonases efficiently quench acyl-homoserine lactone-based bacterial quorum sensing, implicating these enzymes as potential new anti-Pseudomonas drugs that might be evaluated in pneumonia.The aim of the present study was to evaluate the ability of a lactonase called SsoPox-I to reduce the mortality of a rat P. aeruginosa pneumonia.To assess SsoPox-I-mediated quorum quenching, we first measured the activity of the virulence gene lasB, the synthesis of pyocianin, the proteolytic activity of a bacterial suspension and the formation of biofilm of a PAO1 strain grown in the presence of lactonase. In an acute lethal model of P. aeruginosa pneumonia in rats, we evaluated the effects of an early or deferred intra-tracheal treatment with SsoPox-I on the mortality, lung bacterial count and lung damage.SsoPox-I decreased PAO1 lasB virulence gene activity, pyocianin synthesis, proteolytic activity and biofilm formation. The early use of SsoPox-I reduced the mortality of rats with acute pneumonia from 75% to 20%. Histological lung damage was significantly reduced but the lung bacterial count was not modified by the treatment. A delayed treatment was associated with a non-significant reduction of mortality.These results demonstrate the protective effects of lactonase SsoPox-I in P. aeruginosa pneumonia and open the way for a future therapeutic use.
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