page_banner

Products

Factory Outlets Pd-L1 Mab Bavencio - D-Leucine Cas: 328-38-1 99% White powder – XD BIOCHEM

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

We are also specializing in improving the things management and QC method in order that we could retain terrific edge inside the fiercely-competitive small business for 53081-25-7, 1,4-Dithioerythritol (Dte), Difficult-To-Make Chiral Building Blocks, Objects won certifications together with the regional and international primary authorities. For far a lot more detailed information, make sure you make contact with us!
Factory Outlets Pd-L1 Mab Bavencio - D-Leucine Cas: 328-38-1 99% White powder – XD BIOCHEM Detail:

Catalog Number XD90305
Product Name D-Leucine

CAS

328-38-1

Molecular Formula

C6H13NO2

Molecular Weight

131.17292
Storage Details Ambient
Harmonized Tariff Code 29224985

 

Product Specification

Specific rotation -14 to -16
AS <1ppm
Pb <10ppm
Loss on Drying <0.20%
Assay 99%
Residue on Ignition <0.10%
Cl <0.020%
Appearance White powder

 

Environmental factors, such as the macronutrient composition of the diet, can have a profound impact on risk of diabetes and metabolic syndrome. In the present study we demonstrate how a single, simple dietary factor–leucine–can modify insulin resistance by acting on multiple tissues and at multiple levels of metabolism. Mice were placed on a normal or high fat diet (HFD). Dietary leucine was doubled by addition to the drinking water. mRNA, protein and complete metabolomic profiles were assessed in the major insulin sensitive tissues and serum, and correlated with changes in glucose homeostasis and insulin signaling. After 8 weeks on HFD, mice developed obesity, fatty liver, inflammatory changes in adipose tissue and insulin resistance at the level of IRS-1 phosphorylation, as well as alterations in metabolomic profile of amino acid metabolites, TCA cycle intermediates, glucose and cholesterol metabolites, and fatty acids in liver, muscle, fat and serum. Doubling dietary leucine reve rsed many of the metabolite abnormalities and caused a marked improvement in glucose tolerance and insulin signaling without altering food intake or weight gain. Increased dietary leucine was also associated with a decrease in hepatic steatosis and a decrease in inflammation in adipose tissue. These changes occurred despite an increase in insulin-stimulated phosphorylation of p70S6 kinase indicating enhanced activation of mTOR, a phenomenon normally associated with insulin resistance. These data indicate that modest changes in a single environmental/nutrient factor can modify multiple metabolic and signaling pathways and modify HFD induced metabolic syndrome by acting at a systemic level on multiple tissues. These data also suggest that increasing dietary leucine may provide an adjunct in the management of obesity-related insulin resistance.


Product detail pictures:

Factory Outlets Pd-L1 Mab Bavencio - D-Leucine  Cas: 328-38-1  99%  White powder – XD BIOCHEM detail pictures


Related Product Guide:

Our firm promises all consumers with the first-class products as well as most satisfying post-sale services. We warmly welcome our regular and new consumers to join us for Factory Outlets Pd-L1 Mab Bavencio - D-Leucine Cas: 328-38-1 99% White powder – XD BIOCHEM , The product will supply to all over the world, such as: Bolivia, Milan, Florence, Our company always concentrate on the development of the international market. We've got a lot of customers in Russia , European countries, the USA, the Middle East countries and Africa countries. We always follow that quality is foundation while service is guarantee to meet all customers.
  • The manufacturer gave us a big discount under the premise of ensuring the quality of products, thank you very much, we will select this company again.
    5 Stars By Alice from Palestine - 2018.09.21 11:01
    It is not easy to find such a professional and responsible provider in today's time. Hope that we can maintain long-term cooperation.
    5 Stars By Mavis from Riyadh - 2017.11.11 11:41
    Close

    Factory Outlets Pd-L1 Mab Bavencio - D-Leucine Cas: 328-38-1 99% White powder – XD BIOCHEM