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Europe style for Oncology - L-lysine dihydrochloride Cas: 657-26-1 99% White crystalline powder – XD BIOCHEM

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We have now sophisticated machines. Our solutions are exported to the USA, the UK and so on, enjoying a great reputation amid consumers for Building Blocks, Bristol-Myers Squibb, Anhydrous And Anaerobic Reaction, In order to expand our international market, we mainly supply our oversea customers Top quality performance products and service.
Europe style for Oncology - L-lysine dihydrochloride Cas: 657-26-1 99% White crystalline powder – XD BIOCHEM Detail:

Catalog Number XD90307
Product Name L-lysine dihydrochloride

CAS

657-26-1

Molecular Formula

C6H14N2O2.2[HCl]

Molecular Weight

219.10944
Storage Details Ambient
Harmonized Tariff Code 29224100

Product Specification

Melting Point 200 – 205 Deg C
Water <0.5%
Optical Rotation +15.9
Appearance White crystalline powder
Assay (Titration ex Chloride) >99%

 

Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging disease. One of the main symptoms of this genetic disorder is a loss of sub-cutaneous fat due to a dramatic lipodystrophy.We stably induced the expression of human PG and GFP -Green Fluorescent Protein- as control in 3T3L1 cells using a lentiviral system to study the effect of PG expression in the differentiation capacity of this cell line, one of the most used adipogenic models. Quantitative proteomics (iTRAQ) was done to study the effect of the PG accumulation. Several of the modulated proteins were validated by immunoblotting and real-time PCR. Mitochondrial function was analyzed by measurement of a) the mitochondrial basal activity, b) the superoxide anion production and c) the individual efficiency of the different complex of the respiratory chain.We found that over-expression PG by lentivi ral gene delivery leads to a decrease in the proliferation rate and to defects in adipogenic capacity when compared to the control. Quantitative proteomics analysis showed 181 proteins significantly (p<0.05) modulated in PG-expressing preadipocytes. Mitochondrial function is impaired in PG-expressing cells. Specifically, we have detected an increase in the activity of the complex I and an overproduction of Superoxide anion. Incubation with Reactive Oxygen Species (ROS) scavenger agents drives to a decrease in autophagic proteolysis as revealed by LC3-II/LC3-I ratio.PG expression in 3T3L1 cells promotes changes in several Biological Processes, including structure of cytoskeleton, lipid metabolism, calcium regulation, translation, protein folding and energy generation by the mitochondria. Our data strengthen the contribution of ROS accumulation to the premature aging phenotype and establish a link between mitochondrial dysfunction and loss of proteostasis in HGPS.

 


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Europe style for Oncology - L-lysine dihydrochloride  Cas: 657-26-1  99%  White crystalline powder – XD BIOCHEM detail pictures


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To create much more price for clients is our company philosophy; purchaser growing is our working chase for Europe style for Oncology - L-lysine dihydrochloride Cas: 657-26-1 99% White crystalline powder – XD BIOCHEM , The product will supply to all over the world, such as: Nigeria, Armenia, Bhutan, Our solutions are produced with the best raw materials. Every moment, we constantly improve the production programme. In order to ensure better quality and service, we now have been focusing on the production process. We have got high praise by partner. We are looking forward to establishing business relationship with you.
  • The sales person is professional and responsible, warm and polite, we had a pleasant conversation and no language barriers on communication.
    5 Stars By Barbara from Paraguay - 2017.06.25 12:48
    With a positive attitude of "regard the market, regard the custom, regard the science", the company works actively to do research and development. Hope we have a future business relationships and achieving mutual success.
    5 Stars By Elma from Algeria - 2017.06.19 13:51
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    Europe style for Oncology - L-lysine dihydrochloride Cas: 657-26-1 99% White crystalline powder – XD BIOCHEM