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Europe style for Mes Monohydrate - PMSF Cas: 329-98-6 98.0% white crystalline powder Phenylmethanesulfonyl fluoride (PMSF) – XD BIOCHEM

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Europe style for Mes Monohydrate - PMSF Cas: 329-98-6 98.0% white crystalline powder Phenylmethanesulfonyl fluoride (PMSF) – XD BIOCHEM Detail:

Catalog Number XD90250

Product Name

Phenylmethanesulfonyl fluoride (PMSF)

CAS

329-98-6

Molecular Formula

C7H7FO2S

Molecular Weight

174.1927
Storage Details Ambient

Harmonized Tariff Code

29049900

 

Product Specification

Assay ≥98.0% HPLC
Appearance white crystalline powder

 

PMSF is an irreversible serine/cysteine ​​protease inhibitor commonly used in the preparation of cell lysates.

 

In vitro studies: PMSF (2 mM) inhibited carbachol-stimulated inositol phosphate accumulation by only 15%-19% in the presence of Li+. The inhibition of phosphoinositide turnover by PMSF is due to one or more steps following the breakdown of phosphoinositides [1]. PMSF inhibits acylation of inositol residues of GPI intermediates in the bloodstream of T. brucei. PMSF inhibits glycolipid C formation but not fatty acid remodeling in vitro. PMSF inhibits addition of GPI acylation and ethanolamine phosphatase in procyclic trypanosomes, but not in Hela cells [2].

In vivo studies: PMSF (0.1 mL/10 g b.wt, ip) produced antinociception, as shown by a dose-responsive increase in %MPE in tail-flick latency assessment, but failed to produce clear dose-responsive motor inhibition. Mice that received an intraperitoneal injection of PMSF exhibited cannabinoid effects including antinociception, hypothermia and immobility with ED50 values ​​of 86, 224 and 206 mg/kg, respectively. PMSF (30 mg/kg) pretreatment enhances the effects of anandamide on tail-flick responses (antinociception), locomotor activity and mobility by 5-fold, 10-fold and 8-fold, respectively[3].

Animal experiments: Male ICR mice weighing 18 to 25 g were used in the assay. PMSF was dissolved in sesame oil and administered intraperitoneally in a volume of 0.1 mL/10 g b.wt. Always administer PMSF 10 minutes prior to intravenous anandamide or vehicle injection. Mice were acclimated to the evaluation room overnight without interruption of food or water. Following intravenous anandamide or vehicle administration, each animal was evaluated as follows: 5 minutes for tail-flick latency (antinociceptive) responses and 5 to 15 minutes for spontaneous (motor) activity; or 5 minutes for core (rectal) temperature and ring Immobilization (catalepsy) for 5 to 10 minutes.


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Europe style for Mes Monohydrate - PMSF Cas: 329-98-6 98.0%  white crystalline powder Phenylmethanesulfonyl fluoride (PMSF) – XD BIOCHEM detail pictures


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Our company aims to operating faithfully, serving to all of our customers , and working in new technology and new machine constantly for Europe style for Mes Monohydrate - PMSF Cas: 329-98-6 98.0% white crystalline powder Phenylmethanesulfonyl fluoride (PMSF) – XD BIOCHEM , The product will supply to all over the world, such as: Guinea, Puerto Rico, Estonia, Today, We are with great passion and sincerity to further fulfill our global customers' needs with good quality and design innovation. We fully welcome customers from all over the world to establish stable and mutually beneficial business relationships, to have a bright future together.
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    Europe style for Mes Monohydrate - PMSF Cas: 329-98-6 98.0% white crystalline powder Phenylmethanesulfonyl fluoride (PMSF) – XD BIOCHEM