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Cytidine Cas:65-46-3 White crystalline powder 99%

Short Description:

Catalog Number: XD90586
Cas: 65-46-3
Molecular Formula: C9H13N3O5
Molecular Weight: 243.22
Availability: In Stock
Price:  
Prepack: 25g USD10
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Product Detail

Product Tags

Catalog Number XD90586
Product Name Cytidine

CAS

65-46-3

Molecular Formula

C9H13N3O5

Molecular Weight

243.22
Storage Details Ambient
Harmonized Tariff Code 29349990

 

Product Specification

Appearance White crystalline powder
Assay 99%
Heavy metals <20ppm
Chemical Formula C9H13N3O5
Loss on Drying <0.5 %
Residue on Ignition <0.10 %

 

Cellular supply of deoxynucleoside triphosphates (dNTPs) is crucial for DNA replication and repair. In this study, we investigated the role of CMP/UMP kinase (CMPK), an enzyme catalyzes CDP formation, in DNA repair. Knockdown of CMPK delays DNA repair during recovery from UV damage in serum-deprived cells but not in the cells without serum deprivation. Exogenous supply of cytidine or deoxycytidine facilitates DNA repair dependent on CMPK in serum-deprived cells, suggesting that the synthesis of dCDP or CDP determines the rate of repair. However, CMPK knockdown does not affect the steady state level of dCTP in serum-deprived cells. We then found the localization of CMPK at DNA damage sites and its complex formation with Tip60 and ribonucleotide reductase. Our analysis demonstrated that the N-terminal 32-amino-acid of CMPK is required for its recruitment to DNA damage sites in a Tip60-dependent manner. Re-expression of wild-type but not N-terminus deleted CMPK restores the efficiency of DNA repair in CMPK knockdown cells. We proposed that site-specific dCDP formation via CMPK provides a means to facilitate DNA repair in serum-deprived cells.


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    Cytidine Cas:65-46-3 White crystalline powder 99%