China Competitive Price for Medicine Intermediates – L-Histidine Cas: 71-00-1 98.5% White crystals or crystalline powder – XD BIOCHEM Manufacturer and Supplier

Competitive Price for Medicine Intermediates – L-Histidine Cas: 71-00-1 98.5% White crystals or crystalline powder – XD BIOCHEM

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Competitive Price for Medicine Intermediates – L-Histidine Cas: 71-00-1 98.5% White crystals or crystalline powder – XD BIOCHEM Detail:

Catalog Number	XD90301
Product Name	L-Histidine
CAS	71-00-1
Molecular Formula	C6H9N3O2
Molecular Weight	155.15
Storage Details	Ambient
Harmonized Tariff Code	29332990

Product Specification

Assay	98.5% min
Appearance	White crystals or crystalline powder
Grade	USP39
Specific rotation	+12.6 ° to +14.0 °
Identification	Infrared absorption
pH	7.0 – 8.5
SO4	<=0.03%
Fe	<=30ppm
Loss on Drying	<=0.2%
Residue on Ignition	<=0.1%
Cl	<=0.05%
Heavy metals ( PB )	<=15ppm
Related componds	Not more than 0.5% of any individual impurity is found; Not more than 2.0% of total impurities is found

he quadruplex forming G-rich sequences are unevenly distributed throughout the human genome. Their enrichment in oncogenic promoters and telomeres has generated interest in targeting G-quadruplex (GQ) for an anticancer therapy. Here, we present a quantitative analysis on the conformations and dynamics of GQ forming sequences measured by single molecule fluorescence. Additionally, we relate these properties to GQ targeting ligands and G4 resolvase 1 (G4R1) protein binding. Our result shows that both the loop (non-G components) length and sequence contribute to the conformation of the GQ. Real time single molecule traces reveal that the folding dynamics also depend on the loop composition. We demonstrate that GQ-stabilizing small molecules, N-methyl mesoporphyrin IX (NMM), its analog, NMP and the G4R1 protein bind selectively to the parallel GQ conformation. Our findings point to the complexity of GQ folding governed by the loop length and sequence and how the GQ conformation determines the small molecule and protein binding propensity.

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