Competitive Price for Medicine Intermediates – D-Valine Cas: 640-68-6 C5H11NO2 – XD BIOCHEM
Competitive Price for Medicine Intermediates – D-Valine Cas: 640-68-6 C5H11NO2 – XD BIOCHEM Detail:
Catalog Number | XD90291 |
Product Name | D-Valine |
CAS |
640-68-6 |
Molecular Formula |
C5H11NO2 |
Molecular Weight |
117.14634 |
Storage Details | Room Temp |
Harmonized Tariff Code |
29224995 |
Product Specification
Assay | 99% |
Appearance | White powder |
Density | 1.2000 (estimate) |
Melting point | >295 °C (subl.) (lit.) |
Boiling point | 213.6 °C at 760 mmHg |
Flash point | 83℃ |
Refractive index | -27 ° (C=8, 6mol/L HCl) |
Solubility | 56 g/L (20°C) |
Water solubility | 56 g/L (20 ºC) |
PSA | 63.32000 |
LogP | 0.75460 |
Specific rotation | -27.5 º (c=5, 5N HCl) |
Optical activity | [α]23/D −32.0 to −24.0°, c = 8 in 6 M HCl |
Women with antiphospholipid syndrome (APS) are at increased risk of recurrent pregnancy loss (RPL) and preeclampsia. Antiphospholipid antibodies (aPL) directly alter trophoblast function. Treatment with low molecular weight heparin (LMWH) reduces the risk of RPL but not preeclampsia. Moreover, LMWH stimulates trophoblast sFlt-1 release, an anti-angiogenic factor associated with preeclampsia. Since vitamin D deficiency is associated with APS and preeclampsia, this study sought to determine the effect of vitamin D on trophoblast function in the setting of aPL and LMWH.A human first trimester trophoblast cell line (HTR8) and primary trophoblast cultures were treated with or without aPL in the presence and absence of vitamin D, LMWH or both. Trophoblast secretion of inflammatory cytokines and angiogenic factors were measured by ELISA.Vitamin D alone or in combination with LMWH attenuated the aPL-induced trophoblast inflammatory response in the HTR8 cells and primary cultures. While vitamin D did not have any impact on aPL-mediated modulation of angiogenic factors in the primary trophoblast, it significantly inhibited LMWH-induced sFlt-1 release.LMWH in combination with vitamin D may be more beneficial than single-agent therapy by preventing aPL-induced trophoblast inflammation and reversing LMWH-induced sFlt-1 secretion.
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Fast and great quotations, informed advisers to help you choose the correct solution that suits all your requirements, a short creation time, responsible top quality manage and distinct providers for paying and shipping affairs for Competitive Price for Medicine Intermediates – D-Valine Cas: 640-68-6 C5H11NO2 – XD BIOCHEM , The product will supply to all over the world, such as: Morocco, Uganda, Albania, Till now, the goods list has been updated regularly and attracted clients from around the globe. Detailed facts is often obtained in our web-site and you'll be served with premium quality consultant service by our after-sale group. They are going to help you get comprehensive acknowledge about our products and make a satisfied negotiation. Company go to to our factory in Brazil is also welcome at any time. Hope to obtain your inquiries for any pleased co-operation.
By Kay from Boston - 2018.09.12 17:18
Factory equipment is advanced in the industry and the product is fine workmanship, moreover the price is very cheap, value for money!
By David Eagleson from Brasilia - 2018.06.26 19:27