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Cis-Dichlorodiammine platinum(Ⅱ), commonly referred to as cisplatin, is a widely used platinum-based chemotherapy drug. It belongs to the family of platinum coordination compounds and is known for its potent antitumor activity against a variety of cancers.Cisplatin works by interfering with the DNA replication process in rapidly dividing cancer cells. It forms covalent bonds with DNA strands, leading to the cross-linking and subsequent structural changes in the DNA molecule. This disrupts DNA replication and cellular division, ultimately resulting in cell death.The therapeutic applications of cisplatin encompass numerous types of cancer, including testicular, ovarian, bladder, lung, head and neck, and cervical cancers. It is often used as a first-line treatment in combination with other anticancer drugs or radiation therapy. Cisplatin has shown particular effectiveness against testicular cancer, contributing to high cure rates when used in combination with other chemotherapeutic agents.The use of cisplatin as a chemotherapy agent has significantly improved the survival rates of cancer patients and has become a cornerstone of modern oncology. Its effectiveness extends to both early-stage and advanced-stage cancers.However, the use of cisplatin is not without side effects. Common adverse effects include nausea, vomiting, kidney damage, hearing loss, and peripheral neuropathy. To mitigate these toxicities, patients may receive pre-treatment with antiemetic drugs and undergo regular monitoring of kidney function.Research continues to explore ways to enhance the efficacy of cisplatin while reducing its side effects. This has led to the development of newer platinum-based compounds and combination therapies that offer improved outcomes and reduced toxicity profiles.In summary, cis-Dichlorodiammine platinum(Ⅱ) (cisplatin) is a platinum-based chemotherapy drug widely used in the treatment of various types of cancer. Its ability to interfere with DNA replication in cancer cells has made it a crucial component in cancer treatment protocols. While associated with side effects, cisplatin has significantly improved patient outcomes and remains a vital tool in the fight against cancer. Ongoing research aims to refine its use and enhance its therapeutic benefits for cancer patients.