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China Supplier Daos - Iodonitrotetrazolium chloride Cas: 146-68-9 98% Light yellow to orange powder – XD BIOCHEM

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Our firm aims to operating faithfully, serving to all of our consumers , and working in new technology and new machine continually for Metabolites, Metabolites, Bristol-Myers Squibb, Our highly specialized process eliminates the component failure and offers our customers unvarying quality, allowing us to control cost, plan capacity and maintain consistent on time delivery.
China Supplier Daos - Iodonitrotetrazolium chloride Cas: 146-68-9 98% Light yellow to orange powder – XD BIOCHEM Detail:

Catalog Number XD90217
Product Name Iodonitrotetrazolium chloride

CAS

146-68-9

Molecular Formula

C19H13ClIN5O2

Molecular Weight

505.70
Storage Details 2 to 8 °C
Harmonized Tariff Code 32129000

 

Product Specification

Identification H-NMR
Solubility Clear solution
Appearance Light yellow to orange powder
Assay HPLC >98%

 

A reciprocal translocation of the ABL1 gene to the BCR gene results in the expression of the oncogenic BCR-ABL1 fusion protein, which characterizes human chronic myeloid leukemia (CML), a myeloproliferative disorder considered invariably fatal until the introduction of the imatinib family of tyrosine kinase inhibitors (TKI). Nonetheless, insensitivity of CML stem cells to TKI treatment and intrinsic or acquired resistance are still frequent causes for disease persistence and blastic phase progression experienced in patients after initial successful therapies. Here, we investigated a possible role for the MAPK15/ERK8 kinase in BCR-ABL1-dependent autophagy, a key process for oncogene-induced leukemogenesis. In this context, we showed the ability of MAPK15 to physically recruit the oncogene to autophagic vesicles, confirming our hypothesis of a biologically relevant role for this MAP kinase in signal transduction by this oncogene. Indeed, by modeling BCR-ABL1 signaling in HeLa cells and t aking advantage of a physiologically relevant model for human CML, i.e. K562 cells, we demonstrated that BCR-ABL1-induced autophagy is mediated by MAPK15 through its ability to interact with LC3-family proteins, in a LIR-dependent manner. Interestingly, we were also able to interfere with BCR-ABL1-induced autophagy by a pharmacological approach aimed at inhibiting MAPK15, opening the possibility of acting on this kinase to affect autophagy and diseases depending on this cellular function. Indeed, to support the feasibility of this approach, we demonstrated that depletion of endogenous MAPK15 expression inhibited BCR-ABL1-dependent cell proliferation, in vitro, and tumor formation, in vivo, therefore providing a novel “druggable” link between BCR-ABL1 and human CML.


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China Supplier Daos - Iodonitrotetrazolium chloride  Cas: 146-68-9  98%  Light yellow to orange powder – XD BIOCHEM detail pictures


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We take "customer-friendly, quality-oriented, integrative, innovative" as objectives. "Truth and honesty" is our management ideal for China Supplier Daos - Iodonitrotetrazolium chloride Cas: 146-68-9 98% Light yellow to orange powder – XD BIOCHEM , The product will supply to all over the world, such as: Porto, Berlin, Muscat, Adhering to the management tenet of "Managing Sincerely, Winning by Quality", we try our best to provide excellent products and service to our clients. We look forward to making progress together with domestic and international clients.
  • This manufacturer can keep improving and perfecting products and service, it is in line with the rules of market competition, a competitive company.
    5 Stars By Meredith from panama - 2018.02.04 14:13
    In general, we are satisfied with all aspects, cheap, high-quality, fast delivery and good procuct style, we will have follow-up cooperation!
    5 Stars By Nainesh Mehta from Panama - 2018.06.18 17:25
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    China Supplier Daos - Iodonitrotetrazolium chloride Cas: 146-68-9 98% Light yellow to orange powder – XD BIOCHEM