China Supplier Daos - 5-Methylphenazinium methosulfate Cas: 299-11-6 99% Dark green to brown powder – XD BIOCHEM
China Supplier Daos - 5-Methylphenazinium methosulfate Cas: 299-11-6 99% Dark green to brown powder – XD BIOCHEM Detail:
Catalog Number | XD90224 |
Product Name | 5-Methylphenazinium methosulfate |
CAS |
299-11-6 |
Molecular Formula |
C14H14N2O4S |
Molecular Weight |
306.337 |
Storage Details | -15 to -20 °C |
Harmonized Tariff Code | 29339980 |
Product Specification
Melting Point | 158-160 °C (dec.)(lit.) |
Assay | 99% |
Form | Solid |
Appearance | Dark green to brown powder |
The n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to enhance the effect of chemotherapeutic drugs in clinical studies in cancer patients and to induce apoptotic tumor cell death in vitro. Until now, EPA and DHA have never been investigated in multiple myeloma (MM). Human myeloma cells (L363, OPM-1, OPM-2 and U266) and normal peripheral blood mononuclear cells were exposed to EPA and DHA, and effects on mitochondrial function and apoptosis, caspase-3 activation, gene expression and drug toxicity were measured. Exposure to EPA and DHA induced apoptosis and increased sensitivity to bortezomib in MM cells. Importantly, they did not affect viability of normal human peripheral mononuclear cells. Messenger RNA expression arrays showed that EPA and DHA modulated genes involved in multiple signaling pathways including nuclear factor (NF) κB, Notch, Hedgehog, oxidative stress and Wnt. EPA and DHA inhibited NFκB activity and induced apo ptosis through mitochondrial perturbation and caspase-3 activation. Our study suggests that EPA and DHA induce selective cytotoxic effects in MM and increase sensitivity to bortezomib and calls for further exploration into a potential application of these n-3 polyunsaturated fatty acids in the therapy of MM
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We emphasize development and introduce new products into the market every year for China Supplier Daos - 5-Methylphenazinium methosulfate Cas: 299-11-6 99% Dark green to brown powder – XD BIOCHEM , The product will supply to all over the world, such as: Norway, Slovakia, Boston, because of our company has been persisting in the management idea of "Survival by Quality, Development by Service, Benefit by Reputation" . We fully realize the good credit standing, the high quality products, the reasonable price and the professional services are the reason that the customers choose us to be their long-term business partner.
By Deborah from Zimbabwe - 2017.02.28 14:19
Although we are a small company, we are also respected. Reliable quality, sincere service and good credit, we are honored to be able to work with you!
By Clementine from Oman - 2018.12.14 15:26