page_banner

Products

China Supplier Amgen - L-lysine dihydrochloride Cas: 657-26-1 99% White crystalline powder – XD BIOCHEM

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

We normally follow the basic principle "Quality Initial, Prestige Supreme". We've been fully committed to offering our consumers with competitively priced good quality merchandise, prompt delivery and professional support for Solid-State Chemistry, 41689-31-0, D-(+)-Cellobiose, We welcome new and old customers from all walks of life to contact us for future business relationships and mutual success.
China Supplier Amgen - L-lysine dihydrochloride Cas: 657-26-1 99% White crystalline powder – XD BIOCHEM Detail:

Catalog Number XD90307
Product Name L-lysine dihydrochloride

CAS

657-26-1

Molecular Formula

C6H14N2O2.2[HCl]

Molecular Weight

219.10944
Storage Details Ambient
Harmonized Tariff Code 29224100

Product Specification

Melting Point 200 – 205 Deg C
Water <0.5%
Optical Rotation +15.9
Appearance White crystalline powder
Assay (Titration ex Chloride) >99%

 

Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging disease. One of the main symptoms of this genetic disorder is a loss of sub-cutaneous fat due to a dramatic lipodystrophy.We stably induced the expression of human PG and GFP -Green Fluorescent Protein- as control in 3T3L1 cells using a lentiviral system to study the effect of PG expression in the differentiation capacity of this cell line, one of the most used adipogenic models. Quantitative proteomics (iTRAQ) was done to study the effect of the PG accumulation. Several of the modulated proteins were validated by immunoblotting and real-time PCR. Mitochondrial function was analyzed by measurement of a) the mitochondrial basal activity, b) the superoxide anion production and c) the individual efficiency of the different complex of the respiratory chain.We found that over-expression PG by lentivi ral gene delivery leads to a decrease in the proliferation rate and to defects in adipogenic capacity when compared to the control. Quantitative proteomics analysis showed 181 proteins significantly (p<0.05) modulated in PG-expressing preadipocytes. Mitochondrial function is impaired in PG-expressing cells. Specifically, we have detected an increase in the activity of the complex I and an overproduction of Superoxide anion. Incubation with Reactive Oxygen Species (ROS) scavenger agents drives to a decrease in autophagic proteolysis as revealed by LC3-II/LC3-I ratio.PG expression in 3T3L1 cells promotes changes in several Biological Processes, including structure of cytoskeleton, lipid metabolism, calcium regulation, translation, protein folding and energy generation by the mitochondria. Our data strengthen the contribution of ROS accumulation to the premature aging phenotype and establish a link between mitochondrial dysfunction and loss of proteostasis in HGPS.

 


Product detail pictures:

China Supplier Amgen - L-lysine dihydrochloride  Cas: 657-26-1  99%  White crystalline powder – XD BIOCHEM detail pictures


Related Product Guide:

With reliable quality process, good reputation and perfect customer service, the series of products produced by our company are exported to many countries and regions for China Supplier Amgen - L-lysine dihydrochloride Cas: 657-26-1 99% White crystalline powder – XD BIOCHEM , The product will supply to all over the world, such as: South Korea, London, Libya, We are seeking the chances to meet all the friends from both at home and abroad for the win-win cooperation. We sincerely hope to have long-term cooperation with all of you on the bases of mutual benefit and common development.
  • We are a small company that has just started, but we get the company leader's attention and gave us a lot of help. Hope we can make progress together!
    5 Stars By Norma from Spain - 2018.06.09 12:42
    It can be said that this is a best producer we encountered in China in this industry, we feel lucky to work with so excellent manufacturer.
    5 Stars By Aaron from Niger - 2018.07.27 12:26
    Close

    China Supplier Amgen - L-lysine dihydrochloride Cas: 657-26-1 99% White crystalline powder – XD BIOCHEM