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China Factory for Mes Sodium Salt - GSH Cas: 70-18-8 98% White crystalline powder – XD BIOCHEM

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China Factory for Mes Sodium Salt - GSH Cas: 70-18-8 98% White crystalline powder – XD BIOCHEM Detail:

Catalog Number XD90227
Product Name GSH

CAS

70-18-8

Molecular Formula

C10H17N3O6S

Molecular Weight

307.323
Storage Details 2 to 8 °C

Harmonized Tariff Code

29309098

 

Product Specification

Product Specification
Melting Point 185°C
Grade Pharma Grade
Heavy metals 10ppm max
Arsenic 2ppm max
Identification IR : Similar with the Reference Spectrum
Loss on Drying 0.5% max
Storage Temperature +20 ° C
Molecular Weight 612.63
Assay 98.0% min
Optical Rotation -15.5°- -17.5 deg
Residue on Ignition 0.1% max
Clarity of Solution Clear and colourless
Appearance White crystalline powder
Related Substance Total: 2.0% max, GSSG:1.5% max

 

The ORF45 protein of Kaposi’s sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early and late stages of KSHV infection. In this study, we surveyed the interactome of ORF45 using a panel of monoclonal antibodies. In addition to the previously identified extracellular regulated kinase (ERK) and p90 ribosomal S6 kinase (RSK) proteins, we found several other copurified proteins, including prominent ones of ∼38 kDa and ∼130 kDa. Mass spectrometry revealed that the 38-kDa protein is viral ORF33 and the 130-kDa protein is cellular USP7 (ubiquitin-specific protease 7). We mapped the ORF33-binding domain to the highly conserved carboxyl-terminal 19 amino acids (aa) of ORF45 and the USP7-binding domain to the reported consensus motif in the central region of ORF45. Using immunofluorescence staining, we observed colocalization of ORF45 with ORF33 or USP7 both under transfected condit ions and in KSHV-infected cells. Moreover, we noticed ORF45-dependent relocalization of a portion of ORF33/USP7 from the nucleus to the cytoplasm. We found that ORF45 caused an increase in ORF33 protein accumulation that was abolished if either the ORF33- or USP7-binding domain in ORF45 was deleted. Furthermore, deletion of the conserved carboxyl terminus of ORF45 in the KSHV genome drastically reduced the level of ORF33 protein in KSHV-infected cells and abolished production of progeny virions. Collectively, our results not only reveal new components of the ORF45 interactome, but also demonstrate that the interactions among these proteins are crucial for KSHV lytic replication.Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of several human cancers. KSHV ORF45 is a multifunctional protein that is required for KSHV lytic replication, but the exact mechanisms by which ORF45 performs its critical functions are unclear. Our previous studies revealed that all ORF45 pr otein in cells exists in high-molecular-weight complexes. We therefore sought to characterize the interactome of ORF45 to provide insights into its roles during lytic replication. Using a panel of monoclonal antibodies, we surveyed the ORF45 interactome in KSHV-infected cells. We identified two new binding partners of ORF45: the viral protein ORF33 and cellular ubiquitin-specific protease 7 (USP7). We further demonstrate that the interaction between ORF45 and ORF33 is crucial for the efficient production of KSHV viral particles, suggesting that the targeted interference with this interaction may represent a novel strategy to inhibit KSHV lytic replication.


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China Factory for Mes Sodium Salt - GSH  Cas: 70-18-8  98%  White crystalline powder – XD BIOCHEM detail pictures


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With our excellent management, strong technical capability and strict quality control system, we continue to provide our clients with reliable quality, reasonable prices and excellent services. We aim at becoming one of your most reliable partners and earning your satisfaction for China Factory for Mes Sodium Salt - GSH Cas: 70-18-8 98% White crystalline powder – XD BIOCHEM , The product will supply to all over the world, such as: Kuwait, Barcelona, New York, Aiming to grow to be by far the most experienced supplier within this sector in Uganda, we keep researching on the creating procedure and raising the high quality of our principal merchandise. Till now, the merchandise list has been updated on a regular basis and attracted customers from around the globe. In depth data can be obtained in our web page and you'll be served with good quality consultant service by our after-sale team. They're about to make it possible for you to get complete acknowledge about our things and make a satisfied negotiation. Small business check out to our factory in Uganda can also be welcome at any time. Hope to obtain your inquiries to get a happy co-operation.
  • The company can keep up with the changes in this industry market, product updates fast and the price is cheap, this is our second cooperation, it's good.
    5 Stars By Coral from St. Petersburg - 2017.09.26 12:12
    The manufacturer gave us a big discount under the premise of ensuring the quality of products, thank you very much, we will select this company again.
    5 Stars By Kevin Ellyson from Brazil - 2018.06.05 13:10
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    China Factory for Mes Sodium Salt - GSH Cas: 70-18-8 98% White crystalline powder – XD BIOCHEM