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Cheapest Price Trastuzumab Enmet - D-Leucine Cas: 328-38-1 99% White powder – XD BIOCHEM

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Cheapest Price Trastuzumab Enmet - D-Leucine Cas: 328-38-1 99% White powder – XD BIOCHEM Detail:

Catalog Number XD90305
Product Name D-Leucine

CAS

328-38-1

Molecular Formula

C6H13NO2

Molecular Weight

131.17292
Storage Details Ambient
Harmonized Tariff Code 29224985

 

Product Specification

Specific rotation -14 to -16
AS <1ppm
Pb <10ppm
Loss on Drying <0.20%
Assay 99%
Residue on Ignition <0.10%
Cl <0.020%
Appearance White powder

 

Environmental factors, such as the macronutrient composition of the diet, can have a profound impact on risk of diabetes and metabolic syndrome. In the present study we demonstrate how a single, simple dietary factor–leucine–can modify insulin resistance by acting on multiple tissues and at multiple levels of metabolism. Mice were placed on a normal or high fat diet (HFD). Dietary leucine was doubled by addition to the drinking water. mRNA, protein and complete metabolomic profiles were assessed in the major insulin sensitive tissues and serum, and correlated with changes in glucose homeostasis and insulin signaling. After 8 weeks on HFD, mice developed obesity, fatty liver, inflammatory changes in adipose tissue and insulin resistance at the level of IRS-1 phosphorylation, as well as alterations in metabolomic profile of amino acid metabolites, TCA cycle intermediates, glucose and cholesterol metabolites, and fatty acids in liver, muscle, fat and serum. Doubling dietary leucine reve rsed many of the metabolite abnormalities and caused a marked improvement in glucose tolerance and insulin signaling without altering food intake or weight gain. Increased dietary leucine was also associated with a decrease in hepatic steatosis and a decrease in inflammation in adipose tissue. These changes occurred despite an increase in insulin-stimulated phosphorylation of p70S6 kinase indicating enhanced activation of mTOR, a phenomenon normally associated with insulin resistance. These data indicate that modest changes in a single environmental/nutrient factor can modify multiple metabolic and signaling pathways and modify HFD induced metabolic syndrome by acting at a systemic level on multiple tissues. These data also suggest that increasing dietary leucine may provide an adjunct in the management of obesity-related insulin resistance.


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The key to our success is "Good Product Quality, Reasonable Price and Efficient Service" for Cheapest Price Trastuzumab Enmet - D-Leucine Cas: 328-38-1 99% White powder – XD BIOCHEM , The product will supply to all over the world, such as: London, Japan, United Arab Emirates, Certainly, competitive price, suitable package and timely delivery will be assured as per customers' demands. We sincerely hope to build business relationship with you on the basis of mutual benefit and profit in the very near future. Warmly welcome to contact us and become our direct cooperators.
  • The customer service reprersentative explained very detailed, service attitude is very good, reply is very timely and comprehensive, a happy communication! We hope to have a opportunity to cooperate.
    5 Stars By Aurora from Uruguay - 2017.12.09 14:01
    The goods we received and the sample sales staff display to us have the same quality, it is really a creditable manufacturer.
    5 Stars By Lauren from Algeria - 2017.09.09 10:18
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    Cheapest Price Trastuzumab Enmet - D-Leucine Cas: 328-38-1 99% White powder – XD BIOCHEM