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Acetyl coenzyme A sodium salt CAS:102029-73-2 White powder

Short Description:

Catalog Number: XD90383
CAS: 102029-73-2
Molecular Formula: C23H38N7O17P3S
Molecular Weight: 809.57
Availability: In Stock
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Prepack: 25g USD20
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Product Detail

Product Tags

Catalog Number XD90383
Product Name Acetyl coenzyme A sodium salt
CAS 102029-73-2
Molecular Formula C23H38N7O17P3S
Molecular Weight 809.57
Storage Details < -10°C
Harmonized Tariff Code 29349990

Product Specification

Assay 99%
Appearance White powder

 

The C6 dicarboxylic acid, adipic acid, is an important platform chemical in industry. Biobased production of adipic acid is a promising alternative to the current petrochemical route. Here, we report biosynthesis of adipic acid using an artificial pathway inspired by the reversal of beta-oxidation of dicarboxylic acids. The biosynthetic pathway comprises condensation of acetyl-CoA and succinyl-CoA to form the C6 backbone and subsequent reduction, dehydration, hydrogenation, and release of adipic acid from its thioester. The pathway was first tested in vitro with reconstituted pathway enzymes and then functionally introduced into Escherichia coli for the biosynthesis and excretion of adipic acid into the culture medium. The production titer was increased by approximately 20-fold through the combination of recruiting enzymes that were more suitable to catalyze the synthetic reactions and increasing availability of the condensation substrates. This work demonstrates direct biosynthesis of adipic acid via non-natural synthetic pathway, which may enable its renewable production.


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    Acetyl coenzyme A sodium salt CAS:102029-73-2 White powder