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5-Nitro-1,10-phenanthroline CAS:4199-88-6 Light yellow to brown crystal

Short Description:

Catalog Number: XD90385
CAS: 4199-88-6
Molecular Formula: C12H7N3O2
Molecular Weight: 225.21
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Product Detail

Product Tags

Catalog Number XD90385
Product Name 5-Nitro-1,10-phenanthroline
CAS 4199-88-6
Molecular Formula C12H7N3O2
Molecular Weight 225.21

 

Product Specification

Melting Point 200 - 203 °C
Assay 99%
Appearance Light yellow to brown crystal

 

Fifteen platinum(II)-based metallointercalators have been synthesised that utilise substituted 1,10-phenanthroline (phen) ligands, including 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10-phenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) and dipyrido[3,2-d:2',3'-f]quinoxaline (dpq), and achiral ethylenediamine (en) and the chiral ancillary ligands 1S,2S-diaminocyclohexane (S,S-dach) and 1R,2R-diaminocyclohexane (R,R-dach). Their cytotoxicity in the L1210 murine leukaemia cell line was determined using growth inhibition assays. The most cytotoxic metal complexes are those that contain S,S-dach ancillary ligands and 5-CH3-phen intercalating ligands. One metallointercalator [Pt(5-CH3-phen)(S,S-dach)]Cl2 (5MESS), displays a 5-10-fold increase in cytotoxicity compared to the clinical agent cisplatin. From DNA binding experiments there appears to be no significant difference between any of the metal complexes, indicating that neither DNA binding affinity nor the mode of binding/DNA adduct formed is the sole determinant of the cytotoxicity of this family of platinum(II)-based metallointercalators.

 


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    5-Nitro-1,10-phenanthroline CAS:4199-88-6 Light yellow to brown crystal