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5-Methylphenazinium methosulfate Cas: 299-11-6 99% Dark green to brown powder

Short Description:

Catalog Number: XD90224
Cas: 299-11-6
Molecular Formula: C14H14N2O4S
Molecular Weight: 306.337
Availability: In Stock
Price:  
Prepack: 25g USD40
Bulk Pack: Request Quote

 


Product Detail

Product Tags

Catalog Number XD90224
Product Name 5-Methylphenazinium methosulfate

CAS

299-11-6

Molecular Formula

C14H14N2O4S

Molecular Weight

306.337
Storage Details -15 to -20 °C
Harmonized Tariff Code 29339980

 

Product Specification

Melting Point 158-160 °C (dec.)(lit.)
Assay 99%
Form Solid
Appearance Dark green to brown powder

 

The n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to enhance the effect of chemotherapeutic drugs in clinical studies in cancer patients and to induce apoptotic tumor cell death in vitro. Until now, EPA and DHA have never been investigated in multiple myeloma (MM). Human myeloma cells (L363, OPM-1, OPM-2 and U266) and normal peripheral blood mononuclear cells were exposed to EPA and DHA, and effects on mitochondrial function and apoptosis, caspase-3 activation, gene expression and drug toxicity were measured. Exposure to EPA and DHA induced apoptosis and increased sensitivity to bortezomib in MM cells. Importantly, they did not affect viability of normal human peripheral mononuclear cells. Messenger RNA expression arrays showed that EPA and DHA modulated genes involved in multiple signaling pathways including nuclear factor (NF) κB, Notch, Hedgehog, oxidative stress and Wnt. EPA and DHA inhibited NFκB activity and induced apo ptosis through mitochondrial perturbation and caspase-3 activation. Our study suggests that EPA and DHA induce selective cytotoxic effects in MM and increase sensitivity to bortezomib and calls for further exploration into a potential application of these n-3 polyunsaturated fatty acids in the therapy of MM


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    5-Methylphenazinium methosulfate Cas: 299-11-6 99% Dark green to brown powder